问荆（木贼科）对链脲佐菌素诱导的糖尿病大鼠胰腺β细胞组织学变化的影响。

The effect of Equisetum arvense L. (Equisetaceae) in histological changes of pancreatic beta-cells in streptozotocin-induced diabetic in rats.

作者信息

Soleimani Safiyeh, Azarbaizani Fathallah Fathi, Nejati Vahid

机构信息

Department of Biology, Faculty of Science, Urmia University, Iran

出版信息

Pak J Biol Sci. 2007 Dec 1;10(23):4236-40. doi: 10.3923/pjbs.2007.4236.4240.

DOI:10.3923/pjbs.2007.4236.4240

PMID:19086577

Abstract

In view of alleged, the methanolic extract of Equisetum arvense was analysed for its antidiabetic activity in streptozotocin-induced diabetic rats. The blood glucose lowering activity of the methanolic extract was determined in streptozotocin-induced (50 mg kg(-1), i.p.; dissolved in normal saline) diabetic rats, after oral administration in doses of 50 and 250 mg kg(-1) daily for 5 weeks. The data was compare statistically using one-way ANOVA tukey test. The results showed methanolic extract of Equisetum arvense produced a significant antidiabetic activity at doses 50 and 50 mg kg(-1)/b.wt. Concurrent histological studies of the pancreas of these animals showed comparable regeneration by methanolic extract which were earlier, necrosed by streptozotocin.

摘要

鉴于此，对问荆的甲醇提取物进行了分析，以研究其对链脲佐菌素诱导的糖尿病大鼠的抗糖尿病活性。在链脲佐菌素诱导（50 mg kg(-1)，腹腔注射；溶于生理盐水）的糖尿病大鼠中，每天口服50和250 mg kg(-1)剂量，持续5周，测定甲醇提取物的降血糖活性。使用单向方差分析Tukey检验对数据进行统计学比较。结果表明，问荆甲醇提取物在50和50 mg kg(-1)/体重剂量下具有显著的抗糖尿病活性。对这些动物胰腺的同时组织学研究表明，甲醇提取物可使胰腺较早前因链脲佐菌素而坏死的部分实现相当程度的再生。