Safiyeh Soleimani, Fathallah Fathiazar Baijani, Vahid Nejati, Hossine Nazemiyeh, Habib Shojaei Sadee
Department of Biology, Faculty of Science, Urmia University, Iran.
Pak J Biol Sci. 2007 May 15;10(10):1661-6. doi: 10.3923/pjbs.2007.1661.1666.
In view of alleged antidiabetic potential effect of the methanol, n-hexan and dichloromethane extracts of Equisetum arvense of blood sugar and body weight in streptozotocin-induced (50 mg kg(-1), i.p. dissolved in normal saline) diabetic rats were investigated. The blood glucose lowering activity of the methanol, n-hexan and dichloromethane extracts was determined in steptozotocin-induced diabetic rats; after oral administration in doses of 50, 100, 250 and 500 mg kg(-1) daily for 5 weeks. The data was compare statistically using one-way ANOVA tukey test. The results showed that in different doses of methanolic extract, dichloromethane extract at doses of 50 and 250 mg kg(-1) and n-hexan extract (50 mg kg(-1)), blood sugar decreased significantly in comparison with the treatment and control groups of diabetic rats. Also the weights of methanolic-extract treatment group were higher than the other treatment groups. The present studies clearly indicate a significant antidiabetic effect with the methanolic extract of Equisetum arvense and lend support for its traditional usage. Further investigation on identification of the active principles and their mode of action are needed to unravel the molecular mechanisms involved in the observed effects.
鉴于问荆的甲醇、正己烷和二氯甲烷提取物据称具有抗糖尿病潜力，研究了其对链脲佐菌素诱导（50 mg kg⁻¹，腹腔注射，溶于生理盐水）的糖尿病大鼠血糖和体重的影响。在链脲佐菌素诱导的糖尿病大鼠中测定甲醇、正己烷和二氯甲烷提取物的降血糖活性；每日按50、100、250和500 mg kg⁻¹的剂量口服给药，持续5周。使用单向方差分析Tukey检验对数据进行统计学比较。结果表明，与糖尿病大鼠的治疗组和对照组相比，不同剂量的甲醇提取物、50和250 mg kg⁻¹剂量的二氯甲烷提取物以及50 mg kg⁻¹剂量的正己烷提取物可使血糖显著降低。此外，甲醇提取物治疗组的体重高于其他治疗组。本研究清楚地表明问荆甲醇提取物具有显著的抗糖尿病作用，并支持其传统用途。需要进一步研究确定活性成分及其作用方式，以阐明所观察到的效应所涉及的分子机制。
