Ozlem Suriye, Akkaya Engin U
Department of Chemistry, Middle East Technical University, TR-06531, Ankara, Turkey.
J Am Chem Soc. 2009 Jan 14;131(1):48-9. doi: 10.1021/ja808389t.
A simple derivative of a well-known dye bodipy appears to be a satisfactory sensitizer for singlet oxygen. Moreover, the rate of singlet oxygen generation can be modulated by two cancer-related cellular parameters, sodium ion concentration and acidity. Singlet oxygen generation rate is maximal when sodium ions and an organic acid were added. The operation of this molecular automaton follows AND logic, which introduces an additional layer of selectivity in the photodynamic action of the reagent. It should also be noted that in this system sensing, computing and actuating functions are realized within a single molecule.
一种著名染料硼二吡咯甲川的简单衍生物似乎是一种令人满意的单线态氧敏化剂。此外，单线态氧的产生速率可由两个与癌症相关的细胞参数——钠离子浓度和酸度来调节。当加入钠离子和一种有机酸时，单线态氧的产生速率最大。这种分子自动机的运行遵循“与”逻辑，这在该试剂的光动力作用中引入了额外的选择性层次。还应注意的是，在这个系统中，传感、计算和驱动功能在单个分子内得以实现。
