JBIR - 23和 - 24，来自链霉菌属AK - AB27的新型抗癌剂。

JBIR-23 and -24, novel anticancer agents from Streptomyces sp. AK-AB27.

作者信息

Motohashi Keiichiro, Hwang Ji-Hwan, Sekido Yoshitaka, Takagi Motoki, Shin-ya Kazuo

机构信息

Biomedicinal Information Research Center, Japan Biological Informatics Consortium, 2-42 Aomi, Koto-ku, Tokyo 135-0064, Japan.

出版信息

Org Lett. 2009 Jan 15;11(2):285-8. doi: 10.1021/ol802611w.

DOI:10.1021/ol802611w

PMID:19086885

Abstract

The screening for active compounds against malignant pleural mesothelioma (MPM) cells produced by Streptomyces sp. AK-AB27 resulted in the isolation of two compounds with a dodecahydrodibenzo[b,d]furan skeleton named JBIR-23 (1) and -24 (2). Their structures were established on the basis of extensive NMR and MS analyses. Compounds 1 and 2 exhibited cytotoxic effects against several MPM cell lines.

摘要

对链霉菌属AK-AB27产生的抗恶性胸膜间皮瘤（MPM）细胞的活性化合物进行筛选，结果分离出两种具有十二氢二苯并[b,d]呋喃骨架的化合物，命名为JBIR-23（1）和-24（2）。它们的结构是在广泛的核磁共振（NMR）和质谱（MS）分析的基础上确定的。化合物1和2对几种MPM细胞系表现出细胞毒性作用。