Tartrolon D，一种来自海洋来源放线菌链霉菌 sp. MDG-04-17-069 的细胞毒性大环二萜。

Tartrolon D, a cytotoxic macrodiolide from the marine-derived actinomycete Streptomyces sp. MDG-04-17-069.

机构信息

Medicinal Chemistry and Microbiology Departments, PharmaMar S.A., Pol. Ind. La Mina Norte, Avenida de los Reyes 1, 28770-Colmenar Viejo (Madrid), Spain.

出版信息

J Nat Prod. 2009 Dec;72(12):2192-4. doi: 10.1021/np9006603.

DOI:10.1021/np9006603

PMID:19968258

Abstract

Exploration of marine-derived actinomycetes as a source of antitumor compounds has led to the isolation of a new member of the tartrolon series, tartrolon D (4). This new compound was obtained from Streptomyces sp. MDG-04-17-069 fermentation broths and displayed strong cytotoxic activity against three human tumor cell lines. Additionally, the known compound ikarugamycin (5) was also found in the culture broths of the same microorganism. The structure of this new tartrolon was established by a combination of spectroscopic techniques (1D and 2D NMR, HRMS, and UV) as well as by comparison with published data for similar compounds.

摘要

海洋来源放线菌作为抗肿瘤化合物的来源的探索导致了一个新的tartrolon 系列成员的分离，即tartrolon D（4）。这种新化合物是从链霉菌 sp. MDG-04-17-069 发酵培养液中获得的，对三种人肿瘤细胞系表现出强烈的细胞毒性活性。此外，在同一微生物的培养物中还发现了已知化合物 ikarugamycin（5）。这个新的 tartrolon 的结构是通过光谱技术（1D 和 2D NMR、高分辨质谱和 UV）的组合以及与类似化合物的已发表数据的比较来确定的。