来自海洋链霉菌的新型细胞毒性吲哚代谢产物。
New cytotoxic indolic metabolites from a marine Streptomyces.
作者信息
Sánchez López José M, Martínez Insua Marta, Pérez Baz Julia, Fernández Puentes José L, Cañedo Hernández Librada M
机构信息
Instituto Biomar, S. A., 24231 Onzonilla, León, Spain.
出版信息
J Nat Prod. 2003 Jun;66(6):863-4. doi: 10.1021/np0204444.
Three new cytotoxic 3,6-disubstituted indoles (1-3) were isolated from the mycelium of a strain identified as Streptomyces sp. (BL-49-58-005), which was separated from a Mexican marine invertebrate, and their structures established by analysis of NMR and mass spectral data. GI(50) values for 1 and 2 in cytotoxic bioassays against a panel of 14 different tumor cell lines were estimated at micromolar range, while compound 3 showed no activity in the same assays.
从一种鉴定为链霉菌属（BL - 49 - 58 - 005）的菌株的菌丝体中分离出三种新的具有细胞毒性的3,6 - 二取代吲哚（1 - 3），该菌株是从一种墨西哥海洋无脊椎动物中分离得到的，通过核磁共振（NMR）和质谱数据分析确定了它们的结构。在针对14种不同肿瘤细胞系的细胞毒性生物测定中，化合物1和2的GI(50)值估计在微摩尔范围内，而化合物3在相同测定中未显示活性。
Zotero 插件