Ding Xiao-fei, Pei Guo-xian, Lin Jin, Wu Tai-xiang
Department of Orthopedic Trauma, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Zhonghua Yi Xue Za Zhi. 2008 Aug 26;88(33):2364-8.
To evaluate and compare the postoperative implant-related complications after treatment of intertrochanteric fracture by gamma nail or by sliding hip screw.
Literatures on randomized controlled trials (RCTs) of the postoperative implant-related complications after treatment of intertrochanteric fracture by gamma nail or by sliding hip screw published before the end of June 2007 were retrieved from Cochrane library, Medline, Embase databank, and Chinese Biomedical Database. Relevant articles were handsearched in several Chinese journals. Methodology quality of the trials was critically assessed and data on postoperative implant-related complications were extracted. The software RevMan4.2.10 provided by the Cochrane Collaboration was used for meta-analysis.
10 RCTs and 3 quasi-RCTs involving 1857 cases were included. The results of meta-analysis showed that gamma nailing significantly increased the rate of postoperative femoral shaft fractures [RR = 3.75, 95%CI (1.47, 9.55), P = 0.006]. However, there were no statistic differences in the rates of lag screw cut-out and total mechanical complications between gamma nail and sliding hip screw treatment.
Compared with sliding hip screw for intertrochanteric fractures, gamma nailing can lead to higher incidence of postoperative femoral shaft fractures. Fracture stability may influence the rate of postoperative implant-related complications. Further large sample and high quality RCTs based on fracture stability are required in order to provide more sufficient and reliable evidence.
评估并比较伽马钉和动力髋螺钉治疗股骨粗隆间骨折术后与植入物相关的并发症。
从Cochrane图书馆、Medline、Embase数据库和中国生物医学数据库中检索2007年6月底前发表的关于伽马钉或动力髋螺钉治疗股骨粗隆间骨折术后与植入物相关并发症的随机对照试验(RCT)文献。在中国的几种期刊中手工检索相关文章。对试验的方法学质量进行严格评估,并提取术后与植入物相关并发症的数据。使用Cochrane协作网提供的RevMan4.2.10软件进行荟萃分析。
纳入10项RCT和3项半随机对照试验,共1857例病例。荟萃分析结果显示,伽马钉显著增加了术后股骨干骨折的发生率[RR = 3.75,95%CI(1.47,9.55),P = 0.006]。然而,伽马钉和动力髋螺钉治疗在拉力螺钉穿出率和总机械并发症发生率方面无统计学差异。
与动力髋螺钉治疗股骨粗隆间骨折相比,伽马钉可导致更高的术后股骨干骨折发生率。骨折稳定性可能影响术后与植入物相关并发症的发生率。需要进一步开展基于骨折稳定性的大样本、高质量RCT,以提供更充分、可靠的证据。