Drummond-Barbosa Daniela
Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
Genetics. 2008 Dec;180(4):1787-97. doi: 10.1534/genetics.108.098244.
Stem cells have a fascinating biology and offer great prospects for therapeutic applications, stimulating intense research on what controls their properties and behavior. Although there have been significant advances in our understanding of how local microenvironments, or niches, control the maintenance and activity of stem cells, it is much less well understood how stem cells sense and respond to variable external, physiological, or tissue environments. This review focuses on the multidirectional interactions among stem cells, niches, tissues, and the systemic environment and on potential ideas for how changes in this network of communication may relate to the aging process.
干细胞具有引人入胜的生物学特性，并为治疗应用提供了广阔前景，激发了人们对控制其特性和行为因素的深入研究。尽管我们在理解局部微环境（即生态位）如何控制干细胞的维持和活性方面取得了重大进展，但对于干细胞如何感知并响应可变的外部、生理或组织环境，我们的了解还非常有限。本综述聚焦于干细胞、生态位、组织和全身环境之间的多向相互作用，以及关于这种通讯网络变化如何与衰老过程相关的潜在观点。
