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RNA编辑酶ADAR1的一种新功能。

A new function for the RNA-editing enzyme ADAR1.

作者信息

Iizasa Hisashi, Nishikura Kazuko

机构信息

Department of Gene Expression and Regulation, Wistar Institute, Philadelphia, Pennsylvania 19104, USA.

出版信息

Nat Immunol. 2009 Jan;10(1):16-8. doi: 10.1038/ni0109-16.

DOI:10.1038/ni0109-16
PMID:19088736
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2945685/
Abstract

ADAR1 catalyzes the deamination of adenosine to inosine in double-stranded RNA. This RNA-editing enzyme is now shown to be involved in hematopoiesis, where it acts to suppress interferon signaling and to block premature apoptosis.

摘要

ADAR1催化双链RNA中腺苷向肌苷的脱氨基反应。现在已表明这种RNA编辑酶参与造血过程,在其中它起到抑制干扰素信号传导并阻止过早凋亡的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f84/2945685/afcbeacc8a7e/nihms234583f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f84/2945685/afcbeacc8a7e/nihms234583f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f84/2945685/afcbeacc8a7e/nihms234583f1.jpg

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本文引用的文献

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Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules.DAI(DLM-1/ZBP1)及其他DNA传感分子对天然免疫反应的调控
Int J Mol Sci. 2020 Aug 27;21(17):6195. doi: 10.3390/ijms21176195.
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Front Cardiovasc Med. 2020 Mar 18;7:30. doi: 10.3389/fcvm.2020.00030. eCollection 2020.
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