Iizasa Hisashi, Nishikura Kazuko
Department of Gene Expression and Regulation, Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Nat Immunol. 2009 Jan;10(1):16-8. doi: 10.1038/ni0109-16.
ADAR1 catalyzes the deamination of adenosine to inosine in double-stranded RNA. This RNA-editing enzyme is now shown to be involved in hematopoiesis, where it acts to suppress interferon signaling and to block premature apoptosis.
ADAR1催化双链RNA中腺苷向肌苷的脱氨基反应。现在已表明这种RNA编辑酶参与造血过程,在其中它起到抑制干扰素信号传导并阻止过早凋亡的作用。