Sokolowski Witold, Metcalfe Annick, Hayashi Shunichi, Yahia L'Hocine, Raymond Jean
Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA 91109, USA.
Biomed Mater. 2007 Mar;2(1):S23-7. doi: 10.1088/1748-6041/2/1/S04. Epub 2007 Mar 2.
Shape memory polymers (SMP) are lightweight, have a high strain/shape recovery ability, are easy to process, and required properties can be tailored for variety of applications. Recently a number of medical applications have been considered and investigated, especially for polyurethane-based SMP. SMP materials were found to be biocompatible, non-toxic and non-mutagenic. The glass transition temperature (T(g)) can be tailored for shape restoration/self-deployment of clinical devices when inserted in the human body. Newly developed SMP foams, together with cold hibernated elastic memory (CHEM) processing, further broaden their potential biomedical applications. Polyurethane-based SMP are described here and major advantages are identified over other medical materials. Some SMP applications are already used in a clinical setting, whereas others are still in development. Lately, several important applications are being considered for CHEM foams as self-deployable vascular and coronary devices. One example is the endovascular treatment of aneurysms.
形状记忆聚合物（SMP）重量轻，具有高应变/形状恢复能力，易于加工，并且可以针对各种应用定制所需性能。最近，人们已经考虑并研究了许多医学应用，特别是基于聚氨酯的SMP。人们发现SMP材料具有生物相容性、无毒且无致突变性。当插入人体时，玻璃化转变温度（T(g)）可以针对临床设备的形状恢复/自我展开进行定制。新开发的SMP泡沫材料，连同冷休眠弹性记忆（CHEM）加工技术，进一步拓宽了它们在生物医学领域的潜在应用。本文介绍了基于聚氨酯的SMP，并指出了其相对于其他医用材料的主要优势。一些SMP应用已经在临床环境中使用，而其他一些仍在开发中。最近，人们正在考虑将CHEM泡沫材料用于一些重要应用，如可自我展开的血管和冠状动脉装置。一个例子是动脉瘤的血管内治疗。
