• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

可生物降解的聚肽。

Biodegradable polydepsipeptides.

机构信息

School of Chemical Engineering and Technology, Tianjin University / Weijin Road 92, 300072 Tianjin, P.R. China.

出版信息

Int J Mol Sci. 2009 Feb;10(2):589-615. doi: 10.3390/ijms10020589. Epub 2009 Feb 13.

DOI:10.3390/ijms10020589
PMID:19333423
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2660651/
Abstract

This paper reviews the synthesis, characterization, biodegradation and usage of bioresorbable polymers based on polydepsipeptides. The ring-opening polymerization of morpholine-2,5-dione derivatives using organic Sn and enzyme lipase is discussed. The dependence of the macroscopic properties of the block copolymers on their structure is also presented. Bioresorbable polymers based on polydepsipeptides could be used as biomaterials in drug controlled release, tissue engineering scaffolding and shape-memory materials.

摘要

本文综述了基于聚二肽的可生物降解聚合物的合成、表征、生物降解和应用。讨论了使用有机锡和酶脂肪酶开环聚合吗啉-2,5-二酮衍生物。还介绍了嵌段共聚物的宏观性质与其结构的关系。基于聚二肽的可生物降解聚合物可用作药物控制释放、组织工程支架和形状记忆材料等生物材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/75499a6e1c9c/ijms-10-00589f13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/7700f9b4a4c2/ijms-10-00589f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/28ee75855d42/ijms-10-00589f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/45e5aa4fbaa1/ijms-10-00589f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/675bbda08738/ijms-10-00589f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/13596c3e1f3b/ijms-10-00589f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/09e49ab9407d/ijms-10-00589f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/5daabe2d69a9/ijms-10-00589f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/1f7f4c16de6e/ijms-10-00589f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/c3db49a09802/ijms-10-00589f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/f5ac8e6edb20/ijms-10-00589f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/f6cfa5dae3cb/ijms-10-00589f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/9d01011dfb70/ijms-10-00589f12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/75499a6e1c9c/ijms-10-00589f13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/7700f9b4a4c2/ijms-10-00589f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/28ee75855d42/ijms-10-00589f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/45e5aa4fbaa1/ijms-10-00589f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/675bbda08738/ijms-10-00589f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/13596c3e1f3b/ijms-10-00589f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/09e49ab9407d/ijms-10-00589f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/5daabe2d69a9/ijms-10-00589f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/1f7f4c16de6e/ijms-10-00589f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/c3db49a09802/ijms-10-00589f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/f5ac8e6edb20/ijms-10-00589f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/f6cfa5dae3cb/ijms-10-00589f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/9d01011dfb70/ijms-10-00589f12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a69f/2660651/75499a6e1c9c/ijms-10-00589f13.jpg

相似文献

1
Biodegradable polydepsipeptides.可生物降解的聚肽。
Int J Mol Sci. 2009 Feb;10(2):589-615. doi: 10.3390/ijms10020589. Epub 2009 Feb 13.
2
Progress in depsipeptide-based biomaterials.基于二肽的生物材料的研究进展。
Macromol Biosci. 2010 Sep 9;10(9):1008-21. doi: 10.1002/mabi.201000076.
3
Degradable depsipeptide-based multiblock copolymers with polyester or polyetherester segments.具有聚酯或聚醚酯链段的可降解基于缩肽的多嵌段共聚物。
Int J Artif Organs. 2011 Feb;34(2):103-9. doi: 10.5301/ijao.2011.6402.
4
Polyhydroxyalkanoates based copolymers.基于聚羟基烷酸酯的共聚物。
Int J Biol Macromol. 2019 Nov 1;140:522-537. doi: 10.1016/j.ijbiomac.2019.08.147. Epub 2019 Aug 19.
5
Biological evaluation of degradable, stimuli-sensitive multiblock copolymers having polydepsipeptide- and poly(ε-caprolactone) segments in vitro.体外研究具有聚二肽和聚己内酯段的可降解、刺激响应性多嵌段共聚物的生物学评价。
Clin Hemorheol Microcirc. 2011;48(1):161-72. doi: 10.3233/CH-2011-1391.
6
Precision Aliphatic Polyesters via Segmer Assembly Polymerization.通过分段组装聚合制备精准脂肪族聚酯。
Molecules. 2018 Feb 18;23(2):452. doi: 10.3390/molecules23020452.
7
Synthesis of Well-Defined Dihydroxy Telechelics by (Co)polymerization of Morpholine-2,5-Diones Catalyzed by Sn(IV) Alkoxide.锡（IV）醇盐催化的吗啉-2,5-二酮（共）聚合合成结构明确的二羟端基聚合物。
Macromol Biosci. 2018 Dec;18(12):e1800257. doi: 10.1002/mabi.201800257. Epub 2018 Oct 14.
8
TBD-Catalyzed Ring-Opening Polymerization of Alkyl-Substituted Morpholine-2,5-Dione Derivatives.TBD 催化的烷基取代吗啉-2,5-二酮衍生物的开环聚合反应。
Macromol Rapid Commun. 2018 Dec;39(23):e1800433. doi: 10.1002/marc.201800433. Epub 2018 Aug 9.
9
Simulation of the Degradation of Cyclic Ketene Acetal and Vinyl-Based Copolymers Synthesized via a Radical Process: Influence of the Reactivity Ratios on the Degradability Properties.通过自由基过程合成的环状酮缩醛和乙烯基共聚物的降解模拟：反应性比对可降解性能的影响。
Macromol Rapid Commun. 2018 Oct;39(19):e1800193. doi: 10.1002/marc.201800193. Epub 2018 May 22.
10
Comments on the ring-opening polymerization of morpholine-2,5-dione derivatives by various metal catalysts and characterization of the products formed in the reactions involving R2SnX2, where X = OPr(i) and NMe2 and R = Bu(n), Ph and p-Me2NC6H4.关于各种金属催化剂引发的吗啉 - 2,5 - 二酮衍生物的开环聚合反应的评论以及在涉及R2SnX2（其中X = OPr(i) 和NMe2且R = Bu(n)、Ph和p-Me2NC6H4）的反应中形成的产物的表征
Dalton Trans. 2006 Feb 14(6):846-51. doi: 10.1039/b510580c. Epub 2005 Nov 3.

引用本文的文献

1
An Optimized and Universal Protocol for the Synthesis of Morpholine-2,5-Diones from Natural Hydrophobic Amino Acids and Their Mixture.一种从天然疏水氨基酸及其混合物合成吗啉 -2,5-二酮的优化通用方法。
ACS Omega. 2024 Jun 17;9(26):28583-28593. doi: 10.1021/acsomega.4c02670. eCollection 2024 Jul 2.
2
In Vivo Application of Carboranes for Boron Neutron Capture Therapy (BNCT): Structure, Formulation and Analytical Methods for Detection.用于硼中子俘获疗法（BNCT）的碳硼烷的体内应用：结构、制剂及检测分析方法
Cancers (Basel). 2023 Oct 11;15(20):4944. doi: 10.3390/cancers15204944.
3
Water-Based Dynamic Depsipeptide Chemistry: Building Block Recycling and Oligomer Distribution Control Using Hydration-Dehydration Cycles.

本文引用的文献

1
Nanostructured Biomaterials for Regeneration.用于再生的纳米结构生物材料
Adv Funct Mater. 2008 Nov 24;18(22):3566-3582. doi: 10.1002/adfm.200800662.
2
2007 AIChE Alpha Chi Sigma Award: From Material to Tissue: Biomaterial Development, Scaffold Fabrication, and Tissue Engineering.2007年美国化学工程师学会阿尔法χ西格玛奖：从材料到组织：生物材料开发、支架制造与组织工程
AIChE J. 2008 Oct 29;54(12):3048-3067. doi: 10.1002/aic.11610.
3
Biodegradable multiblock copolymers based on oligodepsipeptides with shape-memory properties.基于具有形状记忆特性的低聚肽的可生物降解多嵌段共聚物。
水基动态缩肽化学：利用水合-脱水循环实现构建模块回收及低聚物分布控制
JACS Au. 2022 May 17;2(6):1395-1404. doi: 10.1021/jacsau.2c00087. eCollection 2022 Jun 27.
4
Differential Oligomerization of Alpha versus Beta Amino Acids and Hydroxy Acids in Abiotic Proto-Peptide Synthesis Reactions.非生物原肽合成反应中α-氨基酸与β-氨基酸及羟基酸的差异寡聚化
Life (Basel). 2022 Feb 10;12(2):265. doi: 10.3390/life12020265.
5
Biodegradable and Antimicrobial PLA-OLA Blends Containing Chitosan-Mediated Silver Nanoparticles with Shape Memory Properties for Potential Medical Applications.含壳聚糖介导的具有形状记忆特性的银纳米颗粒的可生物降解抗菌聚乳酸-羟基乙酸共聚物共混物在潜在医学应用中的研究
Nanomaterials (Basel). 2020 May 30;10(6):1065. doi: 10.3390/nano10061065.
6
Electrospun Poly(lactide--glycolide--3()-methyl-morpholine-2,5-dione) Nanofibrous Scaffolds for Tissue Engineering.用于组织工程的静电纺聚（丙交酯-乙交酯-3-甲基吗啉-2,5-二酮）纳米纤维支架
Polymers (Basel). 2016 Jan 29;8(2):13. doi: 10.3390/polym8020013.
7
Critical evaluation of biodegradable polymers used in nanodrugs.纳米药物中可生物降解聚合物的评价。
Int J Nanomedicine. 2013;8:3071-90. doi: 10.2147/IJN.S47186. Epub 2013 Aug 19.
Macromol Biosci. 2009 Jan 9;9(1):45-54. doi: 10.1002/mabi.200800199.
4
Hydrogel nanoparticles in drug delivery.用于药物递送的水凝胶纳米颗粒。
Adv Drug Deliv Rev. 2008 Dec 14;60(15):1638-49. doi: 10.1016/j.addr.2008.08.002. Epub 2008 Sep 20.
5
Drug releasing behavior of hybrid micelles containing polypeptide triblock copolymer.含多肽三嵌段共聚物的混合胶束的释药行为。
Biomaterials. 2009 Jan;30(1):108-17. doi: 10.1016/j.biomaterials.2008.09.010. Epub 2008 Oct 5.
6
Nanoparticles for gene transfer to human embryonic stem cell colonies.用于将基因导入人类胚胎干细胞集落的纳米颗粒。
Nano Lett. 2008 Oct;8(10):3126-30. doi: 10.1021/nl8012665. Epub 2008 Aug 29.
7
A biodegradable, immunoprotective, dual nanoporous capsule for cell-based therapies.一种用于细胞疗法的可生物降解、具有免疫保护作用的双纳米多孔胶囊。
Biomaterials. 2008 Nov;29(31):4253-9. doi: 10.1016/j.biomaterials.2008.07.032. Epub 2008 Aug 9.
8
Depsipeptide synthesis.缩肽合成
Methods Mol Biol. 2007;386:321-39. doi: 10.1007/978-1-59745-430-8_13.
9
Recent developments in enzyme-catalyzed ring-opening polymerization.酶催化开环聚合反应的最新进展
Adv Drug Deliv Rev. 2008 Jun 10;60(9):1077-93. doi: 10.1016/j.addr.2008.02.007. Epub 2008 Feb 26.
10
Polymer-drug conjugates: recent development in clinical oncology.聚合物-药物偶联物：临床肿瘤学的最新进展
Adv Drug Deliv Rev. 2008 May 22;60(8):886-98. doi: 10.1016/j.addr.2007.11.009. Epub 2008 Feb 8.