Ilboudo Denise, Karou Damintoti, Nadembega Wendyame M C, Savadogo Aly, Djeneba Ouermi, Pignatelli Salvatore, Pietra Virginio, Bere Augustin, Simpore Jacques, Traore Alfred S
Laboratoire Saint Camille de Ouagadougou, 01 BP 364 Ouagadougou 01, Burkina Faso, Italia.
Pak J Biol Sci. 2007 Sep 1;10(17):2831-7. doi: 10.3923/pjbs.2007.2831.2837.
The aims of this research are: i) to evaluate the prevalence of HHV-8, HBV and HIV among pregnant women, ii) to determine the percentage of these co-infections and iii) to estimate the frequency of the mother-to-child transmission of HIV among HBV and HHV-8 positive mothers. Thus, 379 pregnant women attending ante-natal consultation in Saint Camille Medical Centre were subject to HIV, HHV-8 antibodies and the viral marker Hepatitis B Surface Antigen (HBsAg) detection. We observed 48/379 (12.66%) HIV seropositive subjects. Among them, HIV-1 type infection was predominant (95.83%), only 2/48 (4.17%) subjects had a dual HIV-1 type and HIV-2 type infection, no single HIV-2 type infection was detected. 38/379 (10.02%) subjects were infected by HHV-8 and 30/379 (7.91%) were HBsAg positive. HHV-8 and HIV Co-infections rates were high within HBV positive patients and we had respectively 20.00 and 16.67%. 10.42% HIV positive women were coinfected by HBV while 12.50% were infected by HHV-8. Then, 15.79% subjects HHV-8 positive were co-infected by HBV or HIV. In spite of the PMTCT protocol application, five (10.42%) HIV positive women transmitted the virus to their children. Two HIV positive mothers were co-infected by HHV-8 and one by HBV. Among the 5 HIV infected, one mother (20.0%) was HBV positive and two (40.0%) HHV-8 positive. Although we did not have a large sample which would show large prélalences of the infections, we could put forward that the Co-infection of the HIV with one of these viruses (HBV or HHV-8) could favorite the mother-to-child transmission.
i）评估孕妇中HHV-8、HBV和HIV的感染率；ii）确定这些合并感染的百分比；iii）估计HBV和HHV-8阳性母亲中HIV母婴传播的频率。因此，对在圣卡米尔医疗中心进行产前检查的379名孕妇进行了HIV、HHV-8抗体及病毒标志物乙型肝炎表面抗原（HBsAg）检测。我们观察到48/379（12.66%）名HIV血清学阳性受试者。其中，以HIV-1型感染为主（95.83%），仅有2/48（4.17%）名受试者为HIV-1型和HIV-2型双重感染，未检测到单一HIV-2型感染。38/379（10.02%）名受试者感染了HHV-8，30/379（7.91%）名受试者HBsAg呈阳性。在HBV阳性患者中，HHV-8与HIV的合并感染率较高，分别为20.00%和16.67%。10.42%的HIV阳性女性合并感染了HBV，12.50%合并感染了HHV-8。此外，15.79%的HHV-8阳性受试者合并感染了HBV或HIV。尽管实施了预防母婴传播方案，但仍有5名（10.42%）HIV阳性女性将病毒传播给了她们的孩子。两名HIV阳性母亲合并感染了HHV-8，一名合并感染了HBV。在这5名感染HIV的母亲中，一名母亲（20.0%）HBsAg呈阳性，两名（40.0%）HHV-8阳性。尽管我们没有大量样本显示这些感染的高流行率，但我们可以提出，HIV与这些病毒（HBV或HHV-8）之一的合并感染可能会促进母婴传播。
