Guenther F, Bode C, Faber T
Innere Medizin III, Kardiologie und Angiologie, Universitätsklinikum Freiburg, Freiburg, Germany. felix.guenther@uniklinik-freiburg-de
Dtsch Med Wochenschr. 2009 Jan;134(1-2):23-6. doi: 10.1055/s-0028-1105885. Epub 2008 Dec 17.
PAST HISTORY AND PHYSICAL EXAMINATION: A 38-year-old farmer presented at his general practitioner with dizziness. Physical examination was notable for a heart rate of 35 beats/min. The electrocardiogram (ECG) showed a complete (third degree) heart block with a bradycardic ventricular escape rhythm. The patient reported having had an rash on his right lower leg six weeks previously. After spreading centrifugally it had turned pale in its centre, then regressed and finally disappeared. After having been supplied with a temporary pacemaker in a county hospital the patient was transferred to our hospital.
The ECG showed pacemaker stimulation of the ventricle at about 60 beats/min. Without this stimulation the complete atrioventricular block persisted. Coronary heart disease was excluded by angiography and levocardiography revealed normal systolic left ventricular function. Serological findings were a positive titre of IgG-antibodies against Borrelia while the IgM titre was negative.
The heart block disappeared under antibiotic therapy with ceftriaxon within eight days, after first changing to transitory second and first-degree atrioventricular block, and the pacemaker was removed. The patient did not develop any neurological symptoms.
Cardiac involvement in Lyme disease can be the only manifestation of borreliosis. Possible reversibility under antibiotic therapy is an important aspect of diagnosis. In spite of atypical serology the combination of history, symptoms and serological findings will lead to the diagnosis Lyme disease.
既往史与体格检查:一名38岁农民因头晕就诊于全科医生处。体格检查发现心率为35次/分钟。心电图(ECG)显示完全性(三度)房室传导阻滞,伴有缓慢的心室逸搏心律。患者报告六周前右小腿出现皮疹。皮疹离心性扩散后,中央变苍白,随后消退并最终消失。在县医院安装临时起搏器后,患者被转至我院。
心电图显示起搏器以约60次/分钟的频率刺激心室。若无此刺激,完全性房室传导阻滞持续存在。冠状动脉造影排除了冠心病,左心室造影显示左心室收缩功能正常。血清学检查结果显示抗伯氏疏螺旋体IgG抗体滴度阳性,而IgM滴度阴性。
在使用头孢曲松进行抗生素治疗八天内,房室传导阻滞消失,先是转变为短暂的二度和一度房室传导阻滞,随后起搏器被移除。患者未出现任何神经系统症状。
莱姆病累及心脏可能是疏螺旋体病的唯一表现。抗生素治疗下可能的可逆性是诊断的一个重要方面。尽管血清学检查不典型,但结合病史、症状和血清学检查结果可诊断莱姆病。