Mussalo-Rauhamaa H
Department of Public Health, University of Helsinki, Finland.
Sci Total Environ. 1991 Apr 15;103(2-3):159-75. doi: 10.1016/0048-9697(91)90142-2.
Concentrations of neutral organochlorine compounds (OCs) in blood compartments and adipose tissue were determined in three groups of subjects. In 12 healthy volunteers a positive correlation was found between DDT residue levels in paired serum/adipose tissue samples when the concentrations were calculated on a fat-weight basis (r = 0.74, p less than 0.05); positive correlations were also found for PCB and HCB when the calculations were based on a wet-weight basis (r = 0.68, p less than 0.01; r = 0.69, p less than 0.01). For lindane the correlation coefficient for paired serum/adipose tissue samples was -0.94 (p less than 0.01). The association between adipose tissue and blood cells was weaker than that obtained for serum. These readily obtainable samples are adequate for estimating, or monitoring, the total burden of neutral organochlorines in adipose tissue, especially in cases of low chronic exposure, such as those found in epidemiological studies. In paired liver-adipose tissue samples from 23 autopsy cases, no correlation was found either on a wet- or fat-weight basis. In 131 adults resident in southern and eastern Finland the concentration medians for serum were 1.8, 2.0 and 0.3 ng g-1 wet wt for DDT compounds. PCB and HCB, respectively. This study indicates that monitoring of fat/serum ratios may provide, with tissue concentrations, more information about human exposure to OCs.
在三组受试者中测定了血液各组分和脂肪组织中中性有机氯化合物（OCs）的浓度。在12名健康志愿者中，当以脂肪重量为基础计算浓度时，配对的血清/脂肪组织样本中滴滴涕残留水平之间存在正相关（r = 0.74，p < 0.05）；当以湿重为基础计算时，多氯联苯和六氯苯也存在正相关（r = 0.68，p < 0.01；r = 0.69，p < 0.01）。对于林丹，配对的血清/脂肪组织样本的相关系数为 -0.94（p < 0.01）。脂肪组织与血细胞之间的关联比血清的关联弱。这些易于获取的样本足以估计或监测脂肪组织中中性有机氯的总负荷，特别是在低慢性暴露的情况下，如在流行病学研究中发现的情况。在23例尸检病例的配对肝脏 - 脂肪组织样本中，无论是以湿重还是脂肪重量为基础，均未发现相关性。在芬兰南部和东部居住的131名成年人中，血清中滴滴涕化合物、多氯联苯和六氯苯的浓度中位数分别为1.8、2.0和0.3 ng g-1湿重。这项研究表明，监测脂肪/血清比率可能与组织浓度一起提供更多关于人类接触有机氯的信息。
