Dewailly E, Mulvad G, Pedersen H S, Ayotte P, Demers A, Weber J P, Hansen J C
Unité de Recherche en Santé Publique, Centre Hospitalier Universitaire de Québec, Beauport, Québec, Canada.
Environ Health Perspect. 1999 Oct;107(10):823-8. doi: 10.1289/ehp.99107823.
Organochlorines are persistent lipophilic compounds that accumulate in Inuit people living in circumpolar countries. Organochlorines accumulate as a result of the Inuits' large consumption of sea mammal fat; however, available data are limited to blood lipids, milk fat, and adipose tissue. We report results of organochlorine determination in liver, brain, omental fat, and subcutaneous abdominal fat samples collected from deceased Greenlanders between 1992 and 1994. Eleven chlorinated pesticides and 14 polychlorinated biphenyl congeners were measured in tissue lipid extracts by high-resolution gas chromatography with electron capture detection. Mean concentrations of polychlorinated biphenyls, 2, 2'-bis(4-chlorophenyl)-1,1-dichloroethylene, ss-hexachlorocyclohexane, hexachlorobenzene, mirex, trans-nonachlor, and oxychlordane in adipose tissue samples from Greenlanders were 3-34-fold higher than those measured using the same analytical method in samples from Canadians in Quebec City, Quebec. Brain lipids contained lower concentrations of all organochlorines than lipids extracted from other tissues. Organochlorine residue levels in lipid extracts from liver, omental fat, and subcutaneous abdominal fat samples were similar, with the exception of ss-hexachlorocyclohexane, which reached a greater concentration in liver lipids than in lipids from both adipose tissues (4-fold; p < 0. 05). Comparisons with available international data on adipose tissue levels reveal that the organochlorine body burden in the Inuit population of Greenland is presently among the highest resulting from environmental exposure.
有机氯是持久性亲脂化合物，在居住于环极地国家的因纽特人体内蓄积。因纽特人大量食用海洋哺乳动物脂肪，导致有机氯蓄积；然而，现有数据仅限于血脂、乳脂和脂肪组织。我们报告了1992年至1994年间从已故格陵兰人身上采集的肝脏、大脑、网膜脂肪和腹部皮下脂肪样本中有机氯的测定结果。通过高分辨率气相色谱法和电子捕获检测法，对组织脂质提取物中的11种氯化农药和14种多氯联苯同系物进行了测量。格陵兰人脂肪组织样本中多氯联苯、2,2'-双（4-氯苯基）-1,1-二氯乙烯、β-六氯环己烷、六氯苯、灭蚁灵、反式九氯和氧氯丹的平均浓度，比使用相同分析方法在魁北克市魁北克省加拿大人样本中测得的浓度高3至34倍。大脑脂质中所有有机氯的浓度均低于从其他组织中提取的脂质。肝脏、网膜脂肪和腹部皮下脂肪样本脂质提取物中的有机氯残留水平相似，但β-六氯环己烷除外，其在肝脏脂质中的浓度高于两种脂肪组织脂质中的浓度（4倍；p<0.05）。与现有的关于脂肪组织水平的国际数据比较显示，格陵兰因纽特人群体中有机氯的身体负担目前是环境暴露导致的最高负担之一。
