Palkovičová Murínová Ľubica, Wimmerová Soňa, Lancz Kinga, Patayová Henrieta, Koštiaková Vladimíra, Richterová Denisa, Govarts Eva, Jusko Todd A, Trnovec Tomáš
Department of Environmental Medicine, Faculty of Public Health, Slovak Medical University, Limbová 12, 833 03 Bratislava, Slovakia.
Unit Environmental Risk and Health, VITO NV, Boeretang 200, 2400 Mol, Belgium.
Environ Pollut. 2017 Oct;229:994-999. doi: 10.1016/j.envpol.2017.07.087. Epub 2017 Aug 1.
In epidemiological studies on the toxic effects of prenatal exposure to hexachlorobenzene (HCB), researchers report HCB concentrations, either as wet-weight or per lipid weight basis, in matrices like breast milk, and maternal and cord blood. Conversion of exposures across matrices is needed for comparisons of concentrations and dose effect across cohorts. Using data from a birth cohort study in eastern Slovakia, we derived the maternal blood to cord blood HCB concentration ratio utilizing measured concentrations in 1027 paired maternal and cord blood samples, on a per-lipid basis. In addition to data from the Slovak study, the maternal milk to maternal serum ratio was summarized from 23 published studies on partitioning of HCB between human milk lipid and blood lipid. We identified two distinct groups of milk:blood ratios, those ≤0.45 and those ≥0.85. We assumed that using partition ratios ≤0.45 will underestimate HCB exposure estimates. Taking into account this precautionary measure, we suggest a conversion ratio of 1.21, which is the median of the 16 ratios identified in our literature review. We consider our estimate as conservative and providing appropriate safety in risk analysis.
在关于产前接触六氯苯（HCB）毒性影响的流行病学研究中，研究人员报告了母乳、母体血液和脐带血等基质中六氯苯的浓度，以湿重或每脂质重量为基础。为了比较不同队列中的浓度和剂量效应，需要在不同基质之间转换接触量。利用斯洛伐克东部一项出生队列研究的数据，我们在每脂质基础上，根据1027对配对的母体和脐带血样本中的测量浓度，得出了母体血液与脐带血中六氯苯浓度的比值。除了斯洛伐克研究的数据外，还从23项关于六氯苯在人乳脂质和血液脂质之间分配的已发表研究中总结了母乳与母体血清的比值。我们确定了两组不同的乳血比值，即≤0.45的和≥0.85的。我们认为使用≤0.45的分配比值会低估六氯苯接触量的估计值。考虑到这一预防措施，我们建议转换比值为1.21，这是我们文献综述中确定的16个比值的中位数。我们认为我们的估计是保守的，并在风险分析中提供了适当的安全性。
