Piersanti Giovanni, Remi Francesco, Fusi Vieri, Formica Mauro, Giorgi Luca, Zappia Giovanni
Institute of Medicinal Chemistry, University of Urbino Carlo Bo, Piazza del Rinascimento 6, 61029 Urbino (PU), Italy.
Org Lett. 2009 Jan 15;11(2):417-20. doi: 10.1021/ol802674r.
A new and efficient synthetic protocol for the preparation of unsymmetrical difunctionalized cyclen and its close derivatives using a modified Ugi reaction (N-split Ugi) is described. The scope of this methodology is further extended by the successful use of various isocyanides, highly functionalized carboxylic acids, and aldehydes.
描述了一种使用改良的乌吉反应（N-拆分乌吉反应）制备不对称双官能化环烯及其类似衍生物的新型高效合成方案。通过成功使用各种异腈、高度官能化的羧酸和醛，进一步扩展了该方法的适用范围。
