Bednarek-Tupikowska G, Tworowska-Bardzinska U, Tupikowski K
Department of Endocrinology, Diabetology and Isotope Treatment, Wroclaw Medical University, Wroclaw, Poland.
J Endocrinol Invest. 2008 Oct;31(10):877-81. doi: 10.1007/BF03346435.
Estrogens have some anti-atherosclerotic properties and they influence nitric oxide (NO) production. The aim of this study was to determine NOx levels in post-menopausal women and the effect of estrogen/estrogen-progesteron therapy (ET/EPT) on plasma NO levels. Eighty postmenopausal women (M1) comprising 26 with surgically induced menopause (ET1), mean age 50.9+/-2.9 yr, and 54 with physiological menopause (EPT1), mean age 50.5+/-3.0 yr, were studied. Forty healthy pre-menopausal women, mean age 48.3+/-2.3 yr were the controls (C). The post-menopausal women were treated for 4 months: group ET1 with ET and group EPT1 with EPT. Serum estradiol (E2), FSH, NOx and lipid profile before and after therapy were measured. NOx levels were lower in group M1 than in group C (8.75+/-1.57 vs 10.27+/-2.62, p<0.01) and increased after hormonal therapy (10.65+/-2.38). NOx concentration showed significant positive correlation with E2 (r=0.25, p<0.05). Total cholesterol (240.9+/-43.2), LDL-cholesterol (155.2+/-33.6), triglycerides (124.8+/-54.1), and apolipoprotein B (1.52+/-0.33) were higher in group M1 than in group C (223.1+/-44.3, 133.0+/-38.2, 108.3+/-52.9, and 1.12+/-0.36, respectively), and after ET/EPT they decreased to the values observed in group C. There were no correlations between NO and lipids or apolipoproteins.
ET and EPT improve NOx synthesis and endothelial relaxation. Medroxyprogesterone acetate added to E2 does not significantly influence NOx levels.
雌激素具有一些抗动脉粥样硬化特性，且会影响一氧化氮（NO）的生成。本研究旨在测定绝经后女性的NOx水平以及雌激素/雌激素 - 孕激素疗法（ET/EPT）对血浆NO水平的影响。研究了80名绝经后女性（M1组），其中26名因手术导致绝经（ET1组），平均年龄50.9±2.9岁，54名生理性绝经（EPT1组），平均年龄50.5±3.0岁。40名健康的绝经前女性，平均年龄48.3±2.3岁作为对照组（C组）。绝经后女性接受4个月治疗：ET1组接受雌激素治疗，EPT1组接受雌激素 - 孕激素治疗。测量治疗前后的血清雌二醇（E2）、促卵泡生成素（FSH）、NOx和血脂谱。M1组的NOx水平低于C组（8.75±1.57 vs 10.27±2.62，p<0.01），激素治疗后升高（10.65±2.38）。NOx浓度与E2呈显著正相关（r = 0.25，p<0.05）。M1组的总胆固醇（240.9±43.2）、低密度脂蛋白胆固醇（155.2±33.6）、甘油三酯（124.8±54.1）和载脂蛋白B（1.52±0.33）高于C组（分别为223.1±44.3、133.0±38.2、108.3±52.9和1.12±0.36），ET/EPT治疗后降至C组观察到的值。NO与血脂或载脂蛋白之间无相关性。
雌激素治疗和雌激素 - 孕激素治疗可改善NOx合成及内皮舒张功能。在雌激素中添加醋酸甲羟孕酮对NOx水平无显著影响。
