Zhang Yan, Hu Sheng-Shou, Zhou Jian-Ye, Sun Han-Song, Tang Yue, Zhang Hao, Zheng Zhe, Li Guo-Rong, Zhu Xiao-Dong, Gui Xin-Min
Research Center for Cardiovascular Regenerative Medicine, Department of Cardiovascular Surgery, Fu Wai Hospital and Cardiovascular Institute, School of Jet Propulsion, Beijing University of Aeronautics and Astronautics, Beijing, China.
ASAIO J. 2009 Jan-Feb;55(1):28-32. doi: 10.1097/MAT.0b013e31818f592f.
A fully implantable, axial flow blood pump has been developed in Fu Wai Hospital aiming for clinical use. This ventricular assist device (VAD), which was developed after numerous CFD analyses for the flow characteristics of the pump, is 58.5-mm long, 30-mm wide (including DC motor), and weighs 240 g. The pump can deliver 5 L/min for pressures of 100 mm Hg over 8,000 rpm. In this study, short-term hemocompatibility effects of the axial left ventricular assist device (LVAD) (FW blood pump) were evaluated in four healthy sheep. The device was implanted into the left ventricular apex of beating hearts. The outflow graft of each device was anastomosed to the descending aorta. The hemolysis, which was evaluated in vivo by free hemoglobin value, was below 30 mg/dL. Evaluation of serum biochemical data showed that implantation of the FW blood pump in sheep with normal hearts did not impair end organ function. Gross and microscopic sections of kidney, liver, and lung revealed no evidence of microemboli. Performance of the pump in vivo was considered sufficient for a LVAD, although further design improvement is necessary in terms of hemolysis and antithrombosis to improve biocompatibility of the pump.
中国医学科学院阜外医院已研发出一款旨在用于临床的完全可植入式轴流血泵。这款心室辅助装置（VAD）是在对泵的流动特性进行大量计算流体动力学（CFD）分析后研制而成的，长58.5毫米，宽30毫米（包括直流电机），重240克。该泵在转速超过8000转/分钟时，能在100毫米汞柱的压力下输送5升/分钟的血流量。在本研究中，对4只健康绵羊评估了轴向左心室辅助装置（LVAD）（阜外血泵）的短期血液相容性效应。该装置被植入跳动心脏的左心室心尖。每个装置的流出移植物与降主动脉进行吻合。通过游离血红蛋白值在体内评估的溶血情况低于30毫克/分升。血清生化数据评估表明，在正常心脏的绵羊中植入阜外血泵不会损害终末器官功能。肾脏、肝脏和肺的大体和显微镜切片均未显示微栓子的迹象。尽管在溶血和抗血栓形成方面需要进一步改进设计以提高泵的生物相容性，但该泵在体内的性能被认为对左心室辅助装置来说是足够的。
