Zhang Y, Hu S-S, Zhou J-Y, Sun H-S, Zhang H, Zheng Z, Zhu X-D, Li G-R, Gui X-M, Zhan Z, Jin D-H
Research Center for Cardiovascular Regenerative Medicine, Fu Wai Hospital, Beijing and Department of Cardiovascular Surgery, Fu Wai Hospital, Beijing - China.
Int J Artif Organs. 2008 Nov;31(11):983-7. doi: 10.1177/039139880803101108.
Various ventricular assist devices (VADs) have been developed for clinical use in recent years. The aim of a multidisciplinary research team at the Fuwai Hospital of the Peking Union Medical College is to design and develop an axial flow left ventricular assist device (LVAD) for adults.
Using Computational Fluid Dynamics (CFD), the inflow characteristics of the axial flow pump were analyzed. After CFD analysis, the axial pump was fabricated using a 5-axis, computer numerical control (CNC) milling machine. Performances of the pump both in vitro and in vivo were tested.
This VAD, which was developed after numerous CFD analyses for the flow characteristics of the pump, is 58.5 mm long, 30 mm wide and weighs 120 g. The pump can deliver 5 lpm for pressures of 100 mmHg over 8500 rpm. The NIH value was 0.01 g/100 L. The hemolysis, which was evaluated in an in vivo test, was a bit higher than the normal value, but remained within an acceptable range.
Performance of the pump in vitro and in vivo was considered sufficient for an LVAD. Further design improvements are being undertaken in terms of hemolysis and thrombosis to improve the biocompatibility of the pump.
近年来已研发出多种用于临床的心室辅助装置（VAD）。北京协和医学院阜外医院的一个多学科研究团队旨在设计并开发一款适用于成人的轴流左心室辅助装置（LVAD）。
使用计算流体动力学（CFD）分析轴流泵的流入特性。经过CFD分析后，使用五轴计算机数控（CNC）铣床制造轴流泵。对该泵在体外和体内的性能进行测试。
这款经过多次针对泵的流动特性进行CFD分析后研发出的VAD，长58.5毫米，宽30毫米，重120克。该泵在转速超过8500转/分钟时，对于100毫米汞柱的压力可输送5升/分钟的流量。NIH值为0.01克/100升。在体内测试中评估的溶血情况略高于正常值，但仍在可接受范围内。
该泵在体外和体内的性能被认为对于LVAD而言是足够的。目前正在针对溶血和血栓形成方面进行进一步的设计改进，以提高泵的生物相容性。
