铁催化α-烯烃与二烯烃的1,4-加成反应。
Iron-catalyzed 1,4-addition of alpha-olefins to dienes.
作者信息
Moreau Benoît, Wu Jessica Y, Ritter Tobias
机构信息
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
出版信息
Org Lett. 2009 Jan 15;11(2):337-9. doi: 10.1021/ol802524r.
PMID:19093845
Abstract
A new intermolecular, stereo- and regioselective iron-catalyzed 1,4-addition of alpha-olefins to 1,3-dienes using as low as 1 mol % of an iminopyridine-ferrous chloride complex was developed. Importantly, both double bonds of the linear 1,4-diene addition products are obtained with absolute stereocontrol.
摘要
开发了一种新的分子间、立体和区域选择性铁催化的α-烯烃与1,3-二烯的1,4-加成反应，该反应使用低至1 mol%的亚氨基吡啶-氯化亚铁配合物。重要的是，线性1,4-二烯加成产物的两个双键都能实现绝对的立体控制。
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