WEN Tie, LIU Ling, NIE Sai
Department of Surgical Emergency, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Zhonghua Wai Ke Za Zhi. 2008 Oct 15;46(20):1579-82.
To explore the relationship of apolipoprotein E (ApoE) genotype with hypertriglyceridemia-associated recurrent acute pancreatitis.
Taking the fasting serum triglyceride (TG) level > or = 2.3 mmol/L as hypertriglyceridemia, ApoE genotypes in 115 patients with hypertriglyceridemia-associated recurrent acute pancreatitis were assessed by polymerase chain reaction. According to the fasting serum TG level, all patients were divided into 3 groups: TG mild elevation group (2.3 mmol/L < or = TG < 5.5 mmol/L, Group A), TG moderate elevation group (5.5 mmol/L < or = TG < 11.3 mmol/L, Group B), and TG severe elevation group (TG > or = 11.3 mmol/L, Group C).
Group C had significantly fewer patients with biliary tract disease, improper diet and heavy alcohol consumption, and significantly more patients with passed history of moderate-severe hypertriglyceridemia than Group A and B (P < 0.05). The proportion of patients with E3/4, E3/2, E2/4 and E2/2 genotypes and gene frequency for epsilon 2 and epsilon 4 alleles are significantly higher in Group C than in Group A and B(P < 0.05). Group B had significantly more patients with E3/2 genotype and higher gene frequency for epsilon 2 allele than Group A (P < 0.05).
Apo epsilon 2 and epsilon 4 alleles are closely related to moderate-severe hypertriglyceridemia-associated recurrent acute pancreatitis.
探讨载脂蛋白E（ApoE）基因多态性与高甘油三酯血症相关性复发性急性胰腺炎的关系。
以空腹血清甘油三酯（TG）水平≥2.3 mmol/L为高甘油三酯血症，采用聚合酶链反应对115例高甘油三酯血症相关性复发性急性胰腺炎患者进行ApoE基因分型。根据空腹血清TG水平，将所有患者分为3组：TG轻度升高组（2.3 mmol/L≤TG＜5.5 mmol/L，A组）、TG中度升高组（5.5 mmol/L≤TG＜11.3 mmol/L，B组）和TG重度升高组（TG≥11.3 mmol/L，C组）。
C组胆道疾病、饮食不当和大量饮酒患者明显少于A组和B组，中重度高甘油三酯血症既往史患者明显多于A组和B组（P＜0.05）。C组E3/4、E3/2、E2/4和E2/2基因型患者比例及ε2和ε4等位基因频率明显高于A组和B组（P＜0.05）。B组E3/2基因型患者明显多于A组，ε2等位基因频率高于A组（P＜0.05）。
Apo ε2和ε4等位基因与中重度高甘油三酯血症相关性复发性急性胰腺炎密切相关。
