Stenfors L E, Räisänen S
Department of Otolaryngology, University of Tromsö, Norway.
Acta Otolaryngol. 1991;111(3):562-8. doi: 10.3109/00016489109138384.
In vivo attachment of beta-haemolytic streptococci Group A (GABHS) to the epithelial cells of the palatine tonsils was determined in 10 patients with current acute tonsillitis (AT-group) and in 10 healthy carriers of GABHS (C-group) according to a method described. Standard bacterial culture revealed growth of GABHS in both groups. In the AT-group, massive attachment of streptococcal chains to the tonsillar epithelium was noted. These chains proved positive for FITC-labelled antibodies against beta-haemolytic streptococci, and were only occasionally found in the C-group. The overall bacterial attachment was significantly greater in the AT-group than in the C-group (p less than 0.001). Phenoxymethylpenicillin treatment caused a dramatic decrease in the number of the attached GABHS bacteria within 24 h. Two weeks after completion of the penicillin treatment one individual in each group was still culture-positive for GABHS.
根据所述方法，对10例当前患有急性扁桃体炎的患者（AT组）和10例A组β溶血性链球菌（GABHS）健康携带者（C组）进行了体内GABHS与腭扁桃体上皮细胞的附着测定。标准细菌培养显示两组均有GABHS生长。在AT组中，观察到链球菌链大量附着于扁桃体上皮。这些链对异硫氰酸荧光素标记的抗β溶血性链球菌抗体呈阳性，而在C组中仅偶尔发现。AT组的总体细菌附着明显多于C组（p<0.001）。苯氧甲基青霉素治疗在24小时内使附着的GABHS细菌数量显著减少。青霉素治疗完成两周后，每组仍有1例个体GABHS培养呈阳性。
