Ohmit Suzanne E, Gross Jonathan, Victor John C, Monto Arnold S
University of Michigan School of Public Health, Ann Arbor, MI 48109, USA.
Vaccine. 2009 Feb 11;27(7):1050-4. doi: 10.1016/j.vaccine.2008.11.100. Epub 2008 Dec 16.
Data collected as part of a multi-year trial examining the efficacies of inactivated and live-attenuated influenza vaccines were used to evaluate the reported occurrence of post-vaccination reactions. Two cohorts were defined: (1) individuals who received the same vaccine over two consecutive years, and (2) individuals who first enrolled in year 2 of the study and received vaccine only in that year. For both vaccines there were significantly fewer reactions reported in year 2 in those subjects who were vaccinated both years. Declines were demonstrated when comparing year 1 and 2 reaction frequencies in subjects vaccinated both years, and differences were seen when comparing year 2 reaction frequencies in subjects vaccinated both years with those first vaccinated in year 2. Reaction reporting peaked on post-vaccination days 0 and 1 following receipt of the inactivated vaccine, and on day 2 following receipt of the live-attenuated vaccine.
作为一项多年期试验的一部分收集的数据，该试验旨在检验灭活流感疫苗和减毒活流感疫苗的效力，用于评估报告的接种后反应发生率。定义了两个队列：（1）连续两年接种相同疫苗的个体，以及（2）在研究的第2年首次入组且仅在该年接种疫苗的个体。对于两种疫苗，在两年都接种疫苗的受试者中，第2年报告的反应明显较少。在比较两年都接种疫苗的受试者第1年和第2年的反应频率时显示出下降，并且在比较两年都接种疫苗的受试者与第2年首次接种疫苗的受试者的第2年反应频率时发现了差异。接种灭活疫苗后，反应报告在接种后第0天和第1天达到峰值，接种减毒活疫苗后在第2天达到峰值。
