D'Heilly Sarah J, Blade Mary Ann, Nichol Kristin L
The Medicine Service (111), VA Medical Center, 1 Veterans Drive, Minneapolis, MN 55417, USA.
Vaccine. 2006 May 1;24(18):4024-7. doi: 10.1016/j.vaccine.2005.09.061. Epub 2006 Feb 9.
Nontraditional settings (NTS) are increasingly utilized for adult vaccination but concerns exist about their safety. We conducted this analysis of 542,445 persons vaccinated at an NTS in Minnesota to assess the safety of influenza vaccination in NTS. A total of 112 adverse events (AEs) were reported, 95 immediate and 17 late. Most AEs were mild and resolved within several minutes. 63 persons (.01%) had a vasovagal reaction to vaccination and 22 (.004%) reported an injection site problem. Immediate hypersensitivity reactions were very rare with only 10 (.002%) vaccine recipients having an immediate reaction for which epinephrine was required. Fifteen (.003%) individuals required evaluation in an emergency room or physician's office because of an AE. No deaths were reported. We conclude that influenza vaccine administration in mass vaccination clinics is safe and adverse events after influenza vaccination in NTS are extremely low.
非传统场所（NTS）越来越多地用于成人疫苗接种，但人们对其安全性存在担忧。我们对在明尼苏达州一个非传统场所接种疫苗的542,445人进行了此项分析，以评估在非传统场所接种流感疫苗的安全性。共报告了112例不良事件（AE），其中95例为即时性不良事件，17例为迟发性不良事件。大多数不良事件为轻度，在几分钟内即可缓解。63人（0.01%）对疫苗接种出现血管迷走神经反应，22人（0.004%）报告有注射部位问题。即时超敏反应非常罕见，只有10名（0.002%）疫苗接种者出现需要使用肾上腺素的即时反应。15名（0.003%）个体因不良事件需要在急诊室或医生办公室接受评估。未报告死亡病例。我们得出结论，在大规模疫苗接种诊所接种流感疫苗是安全的，在非传统场所接种流感疫苗后的不良事件发生率极低。
