Department of Chemistry, College of Applied Sciences, University of Samarra, Salahaldin 13/1333, Iraq.
Molecules. 2021 Jan 20;26(3):533. doi: 10.3390/molecules26030533.
A series of new acetamide derivatives - of primary and secondary amines and -toluene sulphinate sodium salt have been synthesized under microwave irradiation and assessed in vitro for their antibacterial activity against one Gram-positive and two Gram-negative bacterial species such as , , and using the Mueller-Hinton Agar diffusion (well diffusion) method. The synthesized compounds with significant differences in inhibition diameters and MICs were compared with those of amoxicillin, ampicillin, cephalothin, azithromycin and doxycycline. All of the evaluated acetamide derivatives were used with varying inhibition concentrations of 6.25, 12.5, 37.5, 62.5, 87.5, 112.5 and 125 µg/mL. The results show that the most important antibacterial properties were displayed by the synthetic compounds and , both of bear a -chlorophenyl moiety incorporated into the 2-position moiety of acetamide . The molecular structures of the new compounds were determined using the FT-IR and H-NMR techniques.
在微波辐射下合成了一系列新的乙酰胺衍生物 - 伯胺和仲胺 - 对甲苯亚磺酸钠盐，并采用 Mueller-Hinton 琼脂扩散（孔扩散）法评估了它们对一种革兰氏阳性和两种革兰氏阴性细菌（如 、 、 ）的体外抗菌活性。将具有显著抑制直径和 MIC 差异的合成化合物与阿莫西林、氨苄西林、头孢噻吩、阿奇霉素和强力霉素进行了比较。所有评估的乙酰胺衍生物均以 6.25、12.5、37.5、62.5、87.5、112.5 和 125 µg/mL 的不同抑制浓度使用。结果表明，具有最重要抗菌性质的是合成化合物 和 ，它们都在乙酰胺的 2-位部分结合了 - 氯苯基部分。新化合物的分子结构通过 FT-IR 和 H-NMR 技术确定。
