Heiene Reidun, Rumsby Gill, Ziener Martine, Dahl Stein A, Tims Christopher, Teige Jon, Ottesen Nina
Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, N-0033 Oslo, Norway.
J Feline Med Surg. 2009 Jun;11(6):474-80. doi: 10.1016/j.jfms.2008.11.003. Epub 2008 Dec 17.
Two unrelated Ragdoll cat mothers in Norway were found dead from renal disease. The histopathology was consistent with oxalate nephrosis with chronic or acute-on-chronic underlying kidney disease. Both cats had offspring and relatives with signs of urinary tract disease, including a kitten dead with urethral gravel. Eleven living Ragdoll cats, including nine relatives of the dead cats and the male father of a litter with similarly affected animals, were tested for primary hyperoxaluria (PH) type 1 and 2 by urine oxalate and liver enzyme analysis. Renal ultrasound revealed abnormalities in five living cats. One of these was azotaemic at the time of examination and developed terminal kidney disease 9 months later. A diagnosis of PH was excluded in 11 cats tested. The inheritance and aetiological background of the renal disease present in the breed remains unresolved at this point in time.
挪威两只无血缘关系的布偶猫母亲死于肾病。组织病理学检查结果与草酸盐肾病相符，潜在的肾脏疾病为慢性或慢性急性发作。这两只猫都有后代和亲属出现泌尿系统疾病的症状，包括一只死于尿道结石的小猫。对11只存活的布偶猫进行了检测，包括9只死猫的亲属以及一窝有类似患病动物的雄性父亲，通过尿液草酸盐和肝酶分析来检测1型和2型原发性高草酸尿症（PH）。肾脏超声检查发现5只存活猫存在异常。其中一只在检查时出现氮血症，9个月后发展为终末期肾病。在接受检测的11只猫中排除了PH的诊断。目前该品种中存在的肾病的遗传和病因背景仍未明确。
