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对抗抗生素耐药性

[Fighting antibiotic resistance].

作者信息

Harthug Stig, Akselsen Per Espen

机构信息

Indremedisinsk institutt Universitetet i Bergen og Regionalt kompetansesenter i sykehushygiene Haukeland Universitetssykehus 5021 Bergen.

出版信息

Tidsskr Nor Laegeforen. 2008 Oct 23;128(20):2343-6.

Abstract

BACKGROUND

Due to the emergence and spread of antibiotic resistance, several infectious diseases are no longer treatable with standard drugs, and in many cases there are no adequate therapeutic options. Even though the situation in the Nordic countries is considerably better than in large parts of the world, we must also contribute to fight this development. In addition to continuing the prudent use of antibiotics, it is important to strengthen certain infection control strategies. WHO has stated that antibiotic resistance is a global health problem.

MATERIAL AND METHODS

The article is based on personal experience from infection control and infectious diseases, and impressions from discussions in National and Nordic forums during the last years. We have also reviewed literature retrieved from non-systematic database searches.

RESULTS AND INTERPRETATION

The introduction of pneumococcal vaccine in the Norwegian Childhood Vaccination Programme will probably contribute to both reducing the use of antibiotics, and preventing the spread of pneumococci that are resistant to antibiotics. Increased influenza vaccination uptake, standard barrier precautions (hand hygiene etc.) against infections in health care institutions, isolation and surveillance of resistant bacteria are among the most important infection control measures that should be strengthened if we are to succeed.

摘要

背景

由于抗生素耐药性的出现和传播,一些传染病已无法用标准药物治疗,而且在许多情况下没有足够的治疗选择。尽管北欧国家的情况比世界上大部分地区要好得多,但我们也必须为应对这种发展做出贡献。除了继续谨慎使用抗生素外,加强某些感染控制策略也很重要。世界卫生组织表示,抗生素耐药性是一个全球健康问题。

材料与方法

本文基于感染控制和传染病方面的个人经验,以及过去几年在国家和北欧论坛上的讨论印象。我们还回顾了从非系统数据库搜索中检索到的文献。

结果与解读

挪威儿童疫苗接种计划中引入肺炎球菌疫苗可能有助于减少抗生素的使用,并防止对抗生素耐药的肺炎球菌传播。如果我们要取得成功,增加流感疫苗接种率、在医疗机构中针对感染采取标准的屏障预防措施(手部卫生等)、隔离和监测耐药细菌是最重要的应加强的感染控制措施。

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