O'Connor James P B, Naish Josephine H, Jackson Alan, Waterton John C, Watson Yvonne, Cheung Sue, Buckley David L, McGrath Deirdre M, Buonaccorsi Giovanni A, Mills Samantha J, Roberts Caleb, Jayson Gordon C, Parker Geoff J M
Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK. james.o'
Magn Reson Med. 2009 Jan;61(1):75-83. doi: 10.1002/mrm.21815.
Magnetic resonance imaging has shown promise for evaluating tissue oxygenation. In this study differences in the tissue longitudinal relaxation rate (R(1)) and effective transverse relaxation rate (R()(2)), induced by inhalation of pure oxygen and carbogen, were evaluated in 10 healthy subjects. Significant reductions in R(1) were demonstrated following both oxygen and carbogen inhalation in the spleen (both P < 0.001), liver (P = 0.002 air vs. oxygen; P = 0.001 air vs. carbogen), skeletal muscle (both P < 0.001), and renal cortex (P = 0.005 air vs. oxygen; P = 0.008 air vs. carbogen). No significant change in R()(2) occurred following pure oxygen in any organ. However, a significant increase in R()(2) was observed in the spleen (P < 0.001), liver (P = 0.001), skeletal muscle (P = 0.026), and renal cortex (P = 0.001) following carbogen inhalation, an opposite effect to that observed in many studies of tumor pathophysiology. Changes in R(1) and R()(2) were independent of the gas administration order in the spleen and skeletal muscle. These findings suggest that the R(1) and R(*)(2) responses to hyperoxic gases are independent biomarkers of oxygen physiology.
磁共振成像已显示出在评估组织氧合方面的前景。在本研究中，对10名健康受试者吸入纯氧和卡波金后组织纵向弛豫率（R(1)）和有效横向弛豫率（R()(2)）的差异进行了评估。在脾脏（两者P < 0.001）、肝脏（空气与氧气比较，P = 0.002；空气与卡波金比较，P = 0.001）、骨骼肌（两者P < 0.001）和肾皮质（空气与氧气比较，P = 0.005；空气与卡波金比较，P = 0.008）中，吸入氧气和卡波金后均显示R(1)显著降低。吸入纯氧后，任何器官的R()(2)均未发生显著变化。然而，吸入卡波金后，脾脏（P < 0.001）、肝脏（P = 0.001）、骨骼肌（P = 0.026）和肾皮质（P = 0.001）的R()(2)显著增加，这与许多肿瘤病理生理学研究中观察到的效应相反。脾脏和骨骼肌中R(1)和R()(2)的变化与气体给药顺序无关。这些发现表明，R(1)和R(*)(2)对高氧气体的反应是氧生理学的独立生物标志物。
