Ahmad Munir, Deng Jun, Lund Molly W, Chen Zhe, Kimmett James, Moran Meena S, Nath Ravinder
Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA.
Phys Med Biol. 2009 Jan 21;54(2):447-65. doi: 10.1088/0031-9155/54/2/018. Epub 2008 Dec 19.
The goal of this work is to present a systematic Monte Carlo validation study on the clinical implementation of the enhanced dynamic wedges (EDWs) into the Pinnacle(3) (Philips Medical Systems, Fitchburg, WI) treatment planning system (TPS) and QA procedures for patient plan verification treated with EDWs. Modeling of EDW beams in the Pinnacle(3) TPS, which employs a collapsed-cone convolution superposition (CCCS) dose model, was based on a combination of measured open-beam data and the 'Golden Segmented Treatment Table' (GSTT) provided by Varian for each photon beam energy. To validate EDW models, dose profiles of 6 and 10 MV photon beams from a Clinac 2100 C/D were measured in virtual water at depths from near-surface to 30 cm for a wide range of field sizes and wedge angles using the Profiler 2 (Sun Nuclear Corporation, Melbourne, FL) diode array system. The EDW output factors (EDWOFs) for square fields from 4 to 20 cm wide were measured in virtual water using a small-volume Farmer-type ionization chamber placed at a depth of 10 cm on the central axis. Furthermore, the 6 and 10 MV photon beams emerging from the treatment head of Clinac 2100 C/D were fully modeled and the central-axis depth doses, the off-axis dose profiles and the output factors in water for open and dynamically wedged fields were calculated using the Monte Carlo (MC) package EGS4. Our results have shown that (1) both the central-axis depth doses and the off-axis dose profiles of various EDWs computed with the CCCS dose model and MC simulations showed good agreement with the measurements to within 2%/2 mm; (2) measured EDWOFs used for monitor-unit calculation in Pinnacle(3) TPS agreed well with the CCCS and MC predictions within 2%; (3) all the EDW fields satisfied our validation criteria of 1% relative dose difference and 2 mm distance-to-agreement (DTA) with 99-100% passing rate in routine patient treatment plan verification using MapCheck 2D diode array.
本研究的目的是针对将增强动态楔形板(EDW)临床应用于Pinnacle(3)(飞利浦医疗系统公司,威斯康星州菲奇堡)治疗计划系统(TPS)以及使用EDW治疗的患者计划验证的质量保证程序,开展一项系统的蒙特卡罗验证研究。在Pinnacle(3) TPS中对EDW射束进行建模,该系统采用坍缩圆锥卷积叠加(CCCS)剂量模型,建模基于实测的开野数据与瓦里安公司针对每种光子束能量提供的“黄金分段治疗表”(GSTT)的组合。为了验证EDW模型,使用Profiler 2(佛罗里达州墨尔本太阳核公司)二极管阵列系统,在虚拟水中针对从近表面到30 cm深度范围内的各种射野尺寸和楔形角,测量了Clinac 2100 C/D的6和10 MV光子束的剂量分布。使用置于中心轴上10 cm深度处的小体积Farmer型电离室,在虚拟水中测量了4至20 cm宽方形射野的EDW输出因子(EDWOF)。此外,对Clinac 2100 C/D治疗头出射的6和10 MV光子束进行了完整建模,并使用蒙特卡罗(MC)软件包EGS4计算了水中开野和动态楔形野的中心轴深度剂量、离轴剂量分布以及输出因子。我们的结果表明:(1)使用CCCS剂量模型和MC模拟计算的各种EDW的中心轴深度剂量和离轴剂量分布与测量结果在2%/2 mm范围内具有良好的一致性;(2)在Pinnacle(3) TPS中用于监测单位计算的实测EDWOF与CCCS和MC预测结果在2%范围内吻合良好;(3)在使用MapCheck 2D二极管阵列进行的常规患者治疗计划验证中,所有EDW射野均满足1%相对剂量差异和2 mm剂量一致距离(DTA)的验证标准,通过率为99 - 100%。