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引入肺炎球菌结合疫苗后，新发现的肺炎球菌6C血清型在鼻咽部的流行率增加。

Increase in the prevalence of the newly discovered pneumococcal serotype 6C in the nasopharynx after introduction of pneumococcal conjugate vaccine.

作者信息

Nahm Moon H, Lin Jisheng, Finkelstein Jonathan A, Pelton Stephen I

机构信息

Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.

出版信息

J Infect Dis. 2009 Feb 1;199(3):320-5. doi: 10.1086/596064.

DOI:10.1086/596064
PMID:19099489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2743180/
Abstract

BACKGROUND

Because pneumococcal serotype 6C was previously not distinguished from serotype 6A, the impact of the 7-valent pneumococcal conjugate vaccine (PCV7) on the carriage of serotype 6C is unknown.

METHODS

The nasopharyngeal (NP) prevalence of the 6C serotype was determined using 1326 pneumococcal isolates collected from 7 cohorts of Massachusetts children between 1994 and 2007. Initially, the isolates were serotyped using the quellung reaction; subsequently, stored specimens of all putative 6A isolates were tested for 6C using monoclonal antibodies. The opsonophagocytic and antibiotic susceptibilities of the isolates were determined.

RESULTS

The prevalence of 6A was 9.6% (33/343) before 2001, 8.0% (18/226) in 2004, and 2.9% (12/416) in 2007. In contrast, the prevalence of 6C was 0.6% (2/343) before 2001, 2.2% (5/226) in 2004, and 8.7% (36/416) in 2007 (P<.001 for 2/343 vs. 36/416). 6C isolates from 2007 were more susceptible to antibiotics than were 6A isolates. PCV7 induced a low ability to opsonize different isolates of 6C.

CONCLUSIONS

Among NP isolates, the prevalence of 6C isolates has increased and the prevalence of 6A isolates has decreased since the introduction of PCV7 in Massachusetts in 2000. The observed increase in serotype 6C prevalence may be explained by the induction by PCV7 of low amounts of functional anti-6C antibody, compared with anti-6A and anti-6B antibodies.

摘要

背景

由于肺炎球菌6C血清型以前未与6A血清型区分开来，所以7价肺炎球菌结合疫苗（PCV7）对6C血清型携带情况的影响尚不清楚。

方法

利用1994年至2007年间从马萨诸塞州7个队列儿童中收集的1326株肺炎球菌分离株，确定6C血清型的鼻咽（NP）流行率。最初，采用荚膜肿胀反应对分离株进行血清分型；随后，使用单克隆抗体对所有假定的6A分离株的保存标本进行6C检测。测定分离株的调理吞噬作用和抗生素敏感性。

结果

2001年前6A的流行率为9.6%（33/343），2004年为8.0%（18/226），2007年为2.9%（12/416）。相比之下，6C的流行率在2001年前为0.6%（2/343），2004年为2.2%（5/226），2007年为8.7%（36/416）（2/343与36/416相比，P<0.001）。2007年的6C分离株比6A分离株对抗生素更敏感。PCV7诱导对不同6C分离株的调理作用能力较低。

结论

自2000年马萨诸塞州引入PCV7以来，在NP分离株中，6C分离株的流行率上升，6A分离株的流行率下降。观察到的6C血清型流行率增加可能是由于与抗6A和抗6B抗体相比，PCV7诱导产生的功能性抗6C抗体量较低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ccc/2743180/dff1e76625e3/nihms123450f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ccc/2743180/dff1e76625e3/nihms123450f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ccc/2743180/dff1e76625e3/nihms123450f1.jpg

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