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中国经典型霍奇金淋巴瘤中ID2蛋白的异常表达及其与EBV-LMP1和P16(INK4A)的相关性

Aberrant expression of ID2 protein and its correlation with EBV-LMP1 and P16(INK4A) in classical Hodgkin lymphoma in China.

作者信息

Zhao Po, Lu Yali, Liu Lin, Zhong Mei

机构信息

Department of Pathology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, PR China.

出版信息

BMC Cancer. 2008 Dec 19;8:379. doi: 10.1186/1471-2407-8-379.

DOI:10.1186/1471-2407-8-379
PMID:19099554
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2625365/
Abstract

BACKGROUND

The relationships between the expression of ID2, EBV-LMP1 and P16(INK4A) in Chinese classical Hodgkin lymphoma are unknown and need exploring.

METHODS

Samples of classical Hodgkin lymphoma from 60 Chinese patients were analyzed for the expression of ID2, EBV-LMP1 and p16(INK4A) proteins by immunohistochemistry.

RESULTS

ID2 protein was expressed in 83.3% of this group of classical Hodgkin lymphoma, staining strongly in both cytoplasm and nucleus of the Hodgkin and Reed-Sternberg (HRS) cells. EBV-LMP1 and P16(INK4A) were overexpressed in 85.0% and 71.7% of Hodgkin lymphoma, respectively. EBV-LMP1 was noted in the cytoplasm, membrane and nucleus of HRS cells; P16(INK4A) was in the nucleus and cytoplasm. Microscopically, ID2, EBV-LMP1 and P16(INK4A) staining distinguished the HRS cells from the complex background of lymphocytes. ID2 was positively correlated with EBV-LMP1(P < 0.01), but P16(INK4A) was inversely related to EBV-LMP1 (P < 0.05).

CONCLUSION

It is suggested that ID2, EBV-LMP1 and P16(INK4A) could play an important role in the evolution of classical Hodgkin lymphoma, and be considered as potential adjunct markers to identify HRS cells in diagnosis.

摘要

背景

中国经典型霍奇金淋巴瘤中ID2、EBV-LMP1和P16(INK4A)的表达之间的关系尚不清楚，需要进行探索。

方法

采用免疫组织化学方法分析60例中国经典型霍奇金淋巴瘤患者样本中ID2、EBV-LMP1和p16(INK4A)蛋白的表达情况。

结果

该组经典型霍奇金淋巴瘤中83.3%表达ID2蛋白，在霍奇金和里德-斯腾伯格（HRS）细胞的细胞质和细胞核中均呈强染色。EBV-LMP1和P16(INK4A)在霍奇金淋巴瘤中的过表达率分别为85.0%和71.7%。EBV-LMP1在HRS细胞的细胞质、细胞膜和细胞核中均有表达；P16(INK4A)在细胞核和细胞质中表达。显微镜下，ID2、EBV-LMP1和P16(INK4A)染色可将HRS细胞与复杂的淋巴细胞背景区分开来。ID2与EBV-LMP1呈正相关（P < 0.01），而P16(INK4A)与EBV-LMP1呈负相关（P < 0.05）。

结论

提示ID2、EBV-LMP1和P16(INK4A)可能在经典型霍奇金淋巴瘤的发生发展中起重要作用，可作为诊断中识别HRS细胞的潜在辅助标志物。

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