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1
Co-production of interleukin-1 and interleukin-6 in tumor cell lines elaborating colony-stimulating factors.在产生集落刺激因子的肿瘤细胞系中白细胞介素-1和白细胞介素-6的共同产生。
Jpn J Cancer Res. 1991 Aug;82(8):890-2. doi: 10.1111/j.1349-7006.1991.tb01917.x.
2
Colony-stimulating factor-producing tumours: production of granulocyte colony-stimulating factor and interleukin-6 is secondary to interleukin-1 production.
Eur J Cancer. 1994;30A(14):2130-6. doi: 10.1016/0959-8049(94)00347-8.
3
IL-1 production as a regulator of G-CSF and IL-6 production in CSF-producing cell lines.白细胞介素-1作为脑脊液生成细胞系中粒细胞集落刺激因子和白细胞介素-6生成调节因子的作用
Br J Cancer. 1992 Apr;65(4):515-8. doi: 10.1038/bjc.1992.106.
4
Paraneoplastic syndrome of hypercalcemia and leukocytosis caused by squamous carcinoma cells (T3M-1) producing parathyroid hormone-related protein, interleukin 1 alpha, and granulocyte colony-stimulating factor.由产生甲状旁腺激素相关蛋白、白细胞介素1α和粒细胞集落刺激因子的鳞状癌细胞（T3M-1）引起的高钙血症和白细胞增多的副肿瘤综合征。
Cancer Res. 1989 Sep 1;49(17):4740-6.
5
Constitutive production of colony-stimulating factors by human hepatoma cell lines: possible correlation with cell differentiation.人肝癌细胞系组成性产生集落刺激因子：与细胞分化的可能相关性。
Exp Hematol. 1996 Feb;24(3):437-44.
6
Interleukin-1 beta and tumor necrosis factor-alpha induce gene expression and production of leukocyte chemotactic factors, colony-stimulating factors, and interleukin-6 in human mesangial cells.白细胞介素-1β和肿瘤坏死因子-α可诱导人系膜细胞中白细胞趋化因子、集落刺激因子和白细胞介素-6的基因表达及产生。
Am J Pathol. 1991 Apr;138(4):991-1003.
7
Hemopoietin-1 activity of interleukin-1 (IL-1) on acute myeloid leukemia colony-forming cells (AML-CFU) in vitro: IL-1 induces production of tumor necrosis factor-alpha which synergizes with IL-3 or granulocyte-macrophage colony-stimulating factor.白细胞介素-1（IL-1）对急性髓性白血病集落形成细胞（AML-CFU）的造血素-1活性：IL-1诱导肿瘤坏死因子-α的产生，其与IL-3或粒细胞-巨噬细胞集落刺激因子协同作用。
Leukemia. 1990 Aug;4(8):557-60.
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Role for cyclic AMP in the postreceptor control of cytokine-stimulated stromal cell growth factor production.环磷酸腺苷在细胞因子刺激的基质细胞生长因子产生的受体后调控中的作用。
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Production of interleukin 1 alpha-like factor and colony-stimulating factor by a squamous cell carcinoma of the thyroid (T3M-5) derived from a patient with hypercalcemia and leukocytosis.一名患有高钙血症和白细胞增多症患者的甲状腺鳞状细胞癌（T3M-5）产生白细胞介素1α样因子和集落刺激因子。
Cancer Res. 1987 Dec 15;47(24 Pt 1):6474-80.
10
Monokine modulation of human astroglial cell production of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor. I. Effects of IL-1 alpha and IL-beta.单核因子对人星形胶质细胞产生粒细胞集落刺激因子和粒细胞巨噬细胞集落刺激因子的调节作用。I. 白细胞介素-1α和白细胞介素-1β的作用
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引用本文的文献

1
IL-1 production as a regulator of G-CSF and IL-6 production in CSF-producing cell lines.白细胞介素-1作为脑脊液生成细胞系中粒细胞集落刺激因子和白细胞介素-6生成调节因子的作用
Br J Cancer. 1992 Apr;65(4):515-8. doi: 10.1038/bjc.1992.106.

本文引用的文献

1
A novel combination of K-ras and myc amplification accompanied by point mutational activation of K-ras in a human lung cancer.在一例人类肺癌中，K-ras和myc扩增的一种新组合，伴有K-ras的点突变激活。
EMBO J. 1984 Dec 1;3(12):2943-6. doi: 10.1002/j.1460-2075.1984.tb02236.x.
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Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin.一种新型人类白细胞介素（BSF-2）的互补DNA，该白细胞介素可诱导B淋巴细胞产生免疫球蛋白。
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Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor.人粒细胞集落刺激因子cDNA的分子克隆与表达
Nature. 1986;319(6052):415-8. doi: 10.1038/319415a0.
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Interleukin 1 regulates hematopoietic activity, a role previously ascribed to hemopoietin 1.白细胞介素1调节造血活性，这一作用先前被归因于造血素1。
Proc Natl Acad Sci U S A. 1987 Aug;84(15):5267-71. doi: 10.1073/pnas.84.15.5267.
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Expression of colony-stimulating factor genes by normal human mesothelial cells and human malignant mesothelioma cells lines in vitro.
Blood. 1989 Aug 15;74(3):940-6.
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Interleukin-6 is not involved in the interleukin-1-induced production of colony-stimulating factors by human bone marrow stromal cells and fibroblasts.白细胞介素-6不参与白细胞介素-1诱导人骨髓基质细胞和成纤维细胞产生集落刺激因子的过程。
Blood. 1989 Dec;74(8):2619-23.
7
Paraneoplastic syndrome of hypercalcemia and leukocytosis caused by squamous carcinoma cells (T3M-1) producing parathyroid hormone-related protein, interleukin 1 alpha, and granulocyte colony-stimulating factor.由产生甲状旁腺激素相关蛋白、白细胞介素1α和粒细胞集落刺激因子的鳞状癌细胞（T3M-1）引起的高钙血症和白细胞增多的副肿瘤综合征。
Cancer Res. 1989 Sep 1;49(17):4740-6.
8
Serum granulocyte colony-stimulating factor levels in healthy volunteers and patients with various disorders as estimated by enzyme immunoassay.通过酶免疫测定法评估健康志愿者和患有各种疾病的患者血清粒细胞集落刺激因子水平。
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9
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.采用酸性硫氰酸胍-苯酚-氯仿萃取法一步分离RNA的方法。
Anal Biochem. 1987 Apr;162(1):156-9. doi: 10.1006/abio.1987.9999.
10
Establishment of a human undifferentiated thyroid cancer cell line producing several growth factors and cytokines.建立一种能产生多种生长因子和细胞因子的人未分化甲状腺癌细胞系。
Cancer. 1990 May 1;65(9):1971-9. doi: 10.1002/1097-0142(19900501)65:9<1971::aid-cncr2820650916>3.0.co;2-v.

在产生集落刺激因子的肿瘤细胞系中白细胞介素-1和白细胞介素-6的共同产生。

Co-production of interleukin-1 and interleukin-6 in tumor cell lines elaborating colony-stimulating factors.

作者信息

Okuno Y, Takahashi T, Suzuki A, Fukumoto M, Nakamura K, Imura H

机构信息

Second Department of Internal Medicine, Faculty of Medicine, Kyoto University.

出版信息

Jpn J Cancer Res. 1991 Aug;82(8):890-2. doi: 10.1111/j.1349-7006.1991.tb01917.x.

DOI:10.1111/j.1349-7006.1991.tb01917.x
PMID:1910025
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5918582/
Abstract

Six carcinoma cell lines elaborating colony-stimulating factors (CSFs) were examined by enzyme-linked immunosorbent assay and Northern blotting to determine whether or not they co-produced interleukin-1 alpha (IL-1 alpha), IL-1 beta and IL-6. All 6 cell lines were co-producers; IL-1 alpha was produced in all 6, IL-6 in 5 and IL-1 beta in 3 of them. These results indicate that IL-1 and IL-6 are commonly co-produced in CSF-producing tumors.

摘要

通过酶联免疫吸附测定法和Northern印迹法对六种分泌集落刺激因子（CSF）的癌细胞系进行检测，以确定它们是否共同产生白细胞介素-1α（IL-1α）、IL-1β和IL-6。所有6种细胞系均为共同生产者；所有6种细胞系均产生IL-1α，5种产生IL-6，3种产生IL-1β。这些结果表明，IL-1和IL-6在产生CSF的肿瘤中通常共同产生。