孕前咨询对降低癫痫女性不良妊娠结局的有效性：证据是什么？
The effectiveness of preconception counseling to reduce adverse pregnancy outcome in women with epilepsy: what's the evidence?
作者信息
Winterbottom Janine, Smyth Rebecca, Jacoby Ann, Baker Gus
机构信息
Epilepsy Department, The Walton Centre for Neurology and Neurosurgery NHS Trust, Lower Lane, Fazakerley, Liverpool, UK.
出版信息
Epilepsy Behav. 2009 Feb;14(2):273-9. doi: 10.1016/j.yebeh.2008.11.008. Epub 2008 Dec 17.
OBJECTIVE
The purpose of this Cochrane review was to determine the effectiveness of delivering preconception counseling interventions to women with epilepsy (WWE) as a means of reducing adverse pregnancy outcomes, increasing knowledge, and increasing intentions to plan pregnancy.
METHODS
Two hundred twenty-five citations were retrieved from a systematic search of the Cochrane Library and electronic databases: Medline (OVID), Scopus, CINAHL, PsychINFO, and ASSIA, and hand searches of relevant epilepsy and obstetric journals.
RESULTS
The search strategy identified 11 studies for consideration for inclusion. However, none met the required criteria for inclusion.
CONCLUSIONS
There is no robust evidence to inform the content, methods of delivery, or likely effectiveness of preconception counseling to improve pregnancy outcomes for WWE and their offspring. The value of counseling WWE prior to conception remains uncertain and requires evaluation in well-designed studies, appropriately powered to detect changes likely associated with both maternal and infant outcomes.
目的
本Cochrane系统评价的目的是确定对癫痫女性（WWE）实施孕前咨询干预措施作为减少不良妊娠结局、增加知识以及增强计划妊娠意愿的一种手段的有效性。
方法
通过对Cochrane图书馆和电子数据库（Medline（OVID）、Scopus、CINAHL、PsychINFO和ASSIA）进行系统检索，并手工检索相关癫痫和产科杂志，共检索到225条引文。
结果
检索策略确定了11项研究以供纳入考虑。然而，没有一项符合纳入的必要标准。
结论
没有有力证据可用于指导孕前咨询的内容、实施方法或其改善WWE及其后代妊娠结局的可能有效性。孕前咨询WWE的价值仍不确定，需要在设计良好、有足够效力以检测可能与母婴结局相关变化的研究中进行评估。
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