Marsh Sharon, Liu Geoffrey
Genome Quebec and Montreal Heart Institute Pharmacogenomics Centre, Montreal, Quebec, Canada.
Adv Drug Deliv Rev. 2009 May 20;61(5):381-7. doi: 10.1016/j.addr.2008.10.003. Epub 2008 Dec 3.
Locally advanced or metastatic breast cancer is typically treated with chemotherapy. Multiple combinations of chemotherapy regimens are available, including anthracyclines, taxanes, antimetabolites, alkylating agents, platinum drugs and vinca alkaloids. This review discusses the pharmacokinetic and pharmacogenomic information available for commonly used breast cancer chemotherapy drugs. Pharmacogenomic associations for many drugs have yet to be identified or validated in breast cancer. Further work is needed to identify markers to screen breast cancer patients prior to therapy selection.
局部晚期或转移性乳腺癌通常采用化疗进行治疗。有多种化疗方案组合可供选择，包括蒽环类、紫杉烷类、抗代谢药、烷化剂、铂类药物和长春花生物碱。本综述讨论了常用乳腺癌化疗药物的药代动力学和药物基因组学信息。许多药物的药物基因组学关联在乳腺癌中尚未得到识别或验证。在选择治疗方案之前，需要进一步开展工作以识别用于筛查乳腺癌患者的标志物。
