Witte John S
Department of Epidemiology and Biostatistics, Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Avenue, Room S965, San Francisco, California 94143-0794, USA.
Nat Rev Genet. 2009 Feb;10(2):77-82. doi: 10.1038/nrg2507. Epub 2008 Dec 23.
Recent genetics and genomics studies of prostate cancer have helped to clarify the genetic basis of this common but complex disease. Genome-wide studies have detected numerous variants associated with disease as well as common gene fusions and expression 'signatures' in prostate tumours. On the basis of these results, some advocate gene-based individualized screening for prostate cancer, although such testing might only be worthwhile to distinguish disease aggressiveness. Lessons learned from these studies provide strategies for further deciphering the genetic causes of prostate cancer and other diseases.
近期对前列腺癌的遗传学和基因组学研究有助于阐明这种常见但复杂疾病的遗传基础。全基因组研究已在前列腺肿瘤中检测到众多与疾病相关的变异以及常见的基因融合和表达“特征”。基于这些结果，一些人主张对前列腺癌进行基于基因的个体化筛查，尽管这种检测可能仅在区分疾病侵袭性方面才有价值。从这些研究中吸取的经验教训为进一步解读前列腺癌及其他疾病的遗传病因提供了策略。
