Yu D, Inman R
University of California, Los Angeles School of Medicine.
Curr Opin Rheumatol. 1991 Aug;3(4):581-5. doi: 10.1097/00002281-199108000-00004.
Because one of the spondyloarthropathies, reactive arthritis, is induced by infections, research into the role of arthritis-causing bacteria has been strongly emphasized. The most remarkable finding in recent years is the detection of some of the bacterial components in the articular compartment, in some cases even several years after the development of arthritis. This location would account for the fact that T lymphocytes in the synovial compartment demonstrate a high in vitro response to preparations of the arthritis-causing bacteria. The persistence of these bacterial components would explain the frequently reported prolonged antibacterial antibody response in arthritis patients. Although the factors leading to the location and persistence of the bacteria are not clear, the finding provides a rationale for treating these patients with long-term antibiotics. A major question being investigated is how the presence of bacterial components in the articular compartment is related to the predominance of HLA-B27 in many of the patients.
由于反应性关节炎作为脊柱关节炎的一种，是由感染诱发的，因此对引发关节炎的细菌所起作用的研究得到了高度重视。近年来最显著的发现是在关节腔中检测到了一些细菌成分，在某些情况下，甚至是在关节炎发病数年之后。这一位置能够解释滑膜腔中的T淋巴细胞在体外对引发关节炎的细菌制剂表现出高度反应这一事实。这些细菌成分的持续存在可以解释关节炎患者中经常报道的持久抗菌抗体反应。尽管导致细菌在该位置存在并持续的因素尚不清楚，但这一发现为使用长期抗生素治疗这些患者提供了理论依据。正在研究的一个主要问题是关节腔中细菌成分的存在与许多患者中HLA - B27的优势地位是如何相关的。
