对嗅鞘胶质细胞具有特异性的聚乙二醇共轭免疫脂质体。

Polyethylene glycol-conjugated immunoliposomes specific for olfactory ensheathing glial cells.

作者信息

Chekhonin V P, Gurina O I, Ykhova O V, Ryabinina A E, Tsibulkina E A, Zhirkov Yu A

机构信息

Laboratory of Immunochemistry, V. P. Serbskii State Research Center of Social and Forensic Psychiatry, Russian Ministry of Health, Russia.

出版信息

Bull Exp Biol Med. 2008 Apr;145(4):449-51. doi: 10.1007/s10517-008-0115-5.

DOI:10.1007/s10517-008-0115-5

PMID:19110591

Abstract

A novel immunoliposome delivery system was developed for directed transport into cultured olfactory epithelium cells. Monoclonal antibodies against glial fibrillary acidic protein (GFAP) served as a vector. Fluorescence microscopy showed that the target cells are specifically stained with Dil dye incorporated into liposomal membranes. This transport system holds promise for the delivery of bioactive substances to olfactory epithelial cells and modulation of their capacity to stimulate axonal regeneration.

摘要

开发了一种新型免疫脂质体递送系统，用于定向转运至培养的嗅觉上皮细胞。抗胶质纤维酸性蛋白（GFAP）的单克隆抗体用作载体。荧光显微镜显示，靶细胞被掺入脂质体膜中的Dil染料特异性染色。该转运系统有望将生物活性物质递送至嗅觉上皮细胞，并调节其刺激轴突再生的能力。