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正常和横断大鼠嗅神经中的胶质纤维酸性蛋白(GFAP)样免疫反应性

Glial fibrillary acidic protein (GFAP)-like immunoreactivity in normal and transected rat olfactory nerve.

作者信息

Barber P C, Dahl D

出版信息

Exp Brain Res. 1987;65(3):681-5. doi: 10.1007/BF00235993.

DOI:10.1007/BF00235993
PMID:3556496
Abstract

Normal and transected rat olfactory nerves were stained immunohistochemically using a monoclonal antibody previously shown to selectively detect GFAP-like immunoreactivity in central astrocytes but not in peripheral Schwann cells. Low levels of "central" type GFAP were found in the olfactory nerves, presumably in ensheathing cells. The levels of GFAP increased dramatically after nerve transection. A population of strongly GFAP-positive cells was detected at the junction between the olfactory epithelium and initial part of the nerves, of possible relevance to the regenerative abilities of this pathway.

摘要

使用一种单克隆抗体对正常和横断的大鼠嗅神经进行免疫组织化学染色,该抗体先前已被证明可选择性检测中枢星形胶质细胞而非外周雪旺细胞中的GFAP样免疫反应性。在嗅神经中发现了低水平的“中枢”型GFAP,可能存在于包绕细胞中。神经横断后,GFAP水平急剧升高。在嗅上皮与神经起始部分的交界处检测到一群强GFAP阳性细胞,这可能与该通路的再生能力有关。

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