Qari Faiza A
King Abdul Aziz University, Jeddah, Saudi Arabia.
Saudi J Kidney Dis Transpl. 2009 Jan;20(1):127-9.
A 52-year-old Indian woman with underlying diabetes mellitus and hyperlipidemia, presented with generalized musculoskeletal pain and oliguria for three days. The patient was taking 80 mg of simvastatin initiated 20 days earlier after cardiac catheterization for an inferior myocardial infarction. Laboratory investigations revealed the following serum levels: creatine kinase 81,620 U/L, aspartate aminotransferase 2497 U/L, alanine aminotransferase 1304 U/L, blood urea nitrogen 21.7 mmol/L, creatinine 447 micromol/L, Free T4 12.6 pmol/L, and thyroid stimulating hormone (TSH) 22.7 microIU/L. Simvastatin was discontinued and the patient received forced alkaline diuresis. Her hypothyroidism was treated with thyroxin, which was continued upon discharge, and her renal function recovered within two months. This case report discusses the incidence of rhabdomyolysis in a patient with primary hypothyroidism receiving large doses of simvastatin.
一名52岁的印度女性，患有糖尿病和高脂血症，出现全身肌肉骨骼疼痛和少尿三天。该患者在因下壁心肌梗死接受心脏导管插入术后20天开始服用80毫克辛伐他汀。实验室检查显示以下血清水平：肌酸激酶81620 U/L，天冬氨酸转氨酶2497 U/L，丙氨酸转氨酶1304 U/L，血尿素氮21.7 mmol/L，肌酐447 μmol/L，游离甲状腺素12.6 pmol/L，促甲状腺激素（TSH）22.7 μIU/L。停用辛伐他汀，患者接受强制碱性利尿治疗。她的甲状腺功能减退用甲状腺素治疗，出院后继续使用，她的肾功能在两个月内恢复。本病例报告讨论了一名原发性甲状腺功能减退患者接受大剂量辛伐他汀治疗后发生横纹肌溶解的发生率。
