Zeki S M, Dudgeon J, Dutton G N
Department of Ophthalmology, Royal Hospital for Sick Children, Glasgow.
Br J Ophthalmol. 1991 Sep;75(9):538-41. doi: 10.1136/bjo.75.9.538.
The ratio of disc to macula/disc diameter is characteristically increased in eyes with optic nerve hypoplasia. We present the largest reported series of patients with a definitive diagnosis of optic nerve hypoplasia for whom this ratio has been determined. All measurements were made by an independent masked observer. Our results are in accordance with previous reports. A ratio of 2.94 provides a one-tailed upper population limit of 95%. An attempt has been made to correlate optic disc size and visual acuity. In 75% of bilateral cases the eye with the relatively smaller optic disc was found to have a better Snellen visual acuity than the fellow eye. This suggests that additional pathogenic mechanism(s) may have determined the eventual visual outcome in such eyes. Such mechanisms include macular hypoplasia, high refractive error, refractive amblyopia, central scotoma, and optic atrophy.
在视神经发育不全的眼中，视盘与黄斑/视盘直径的比值通常会增加。我们报告了已确诊视神经发育不全且已确定该比值的患者中数量最多的系列病例。所有测量均由一名独立的不知情观察者进行。我们的结果与先前的报告一致。2.94的比值给出了95%的单尾总体上限。我们尝试对视盘大小与视力进行相关性分析。在75%的双侧病例中，发现视盘相对较小的眼睛的斯内伦视力比另一只眼睛更好。这表明可能有其他致病机制决定了此类眼睛的最终视觉结果。这些机制包括黄斑发育不全、高度屈光不正、屈光性弱视、中心暗点和视神经萎缩。
