Ownsworth Tamara, Hawkes Anna, Steginga Suzanne, Walker David, Shum David
School of Psychology and Applied Cognitive Neuroscience Research Centre, Griffith University, Brisbane, Australia.
Disabil Rehabil. 2009;31(13):1038-55. doi: 10.1080/09638280802509538.
To systematically evaluate the literature on quality of life and adjustment to brain tumor from a biopsychosocial perspective.
On the basis of the cancer and brain injury literature, a biopsychosocial organisational framework was initially developed to support an evaluative review of the brain tumor literature. This framework consisted of four themes relating to pre-illness characteristics, neuropathology, personal appraisals and reactions and social support. Electronic searches of Medline, PsycINFO and CINAHL databases identified 48 empirical studies (1980-2007) that investigated factors associated with quality of life or the adjustment of adults with brain tumor. A review of studies within each theme appraised these findings and evaluated the quality of methodology and extent to which biopsychosocial perspectives have guided investigations.
Overall, the review identified consistent associations between depression, performance status, fatigue and quality of life. Seven multivariate studies with strong methodology that adopted a biopsychosocial perspective were found. In general, the relationships among pre-illness and brain tumor characteristics, psychosocial variables and quality of life were unclear and various gaps in the literature emerged.
Empirical findings within a biopsychosocial perspective may guide the development and delivery of support services for individuals with brain tumor; however, many important areas exist for future research.
从生物心理社会视角系统评价关于脑肿瘤患者生活质量及适应情况的文献。
基于癌症和脑损伤文献，最初构建了一个生物心理社会组织框架，以支持对脑肿瘤文献的评估性综述。该框架包含与病前特征、神经病理学、个人评估与反应以及社会支持相关的四个主题。通过对Medline、PsycINFO和CINAHL数据库进行电子检索，确定了48项实证研究（1980 - 2007年），这些研究调查了与脑肿瘤成年患者生活质量或适应情况相关的因素。对每个主题内的研究进行综述，评估这些发现，并评价方法学质量以及生物心理社会视角指导研究的程度。
总体而言，该综述确定了抑郁、功能状态、疲劳与生活质量之间存在一致的关联。发现了七项采用生物心理社会视角且方法学严谨的多变量研究。一般来说，病前和脑肿瘤特征、心理社会变量与生活质量之间的关系尚不清楚，文献中出现了各种空白。
生物心理社会视角下的实证研究结果可能会为脑肿瘤患者支持服务的开发与提供提供指导；然而，未来研究仍存在许多重要领域。
