细胞迁移中的整合素——与肌动蛋白的联系
Integrins in cell migration--the actin connection.
作者信息
Vicente-Manzanares Miguel, Choi Colin Kiwon, Horwitz Alan Rick
机构信息
Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
出版信息
J Cell Sci. 2009 Jan 15;122(Pt 2):199-206. doi: 10.1242/jcs.018564.
The connection between integrins and actin is driving the field of cell migration in new directions. Integrins and actin are coupled through a physical linkage, which provides traction for migration. Recent studies show the importance of this linkage in regulating adhesion organization and development. Actin polymerization orchestrates adhesion assembly near the leading edge of a migrating cell, and the dynamic cross-linking of actin filaments promotes adhesion maturation. Breaking the linkage between actin and integrins leads to adhesion disassembly. Recent quantitative studies have revealed points of slippage in the linkage between actin and integrins, showing that it is not always efficient. Regulation of the assembly and organization of adhesions and their linkage to actin relies on signaling pathways that converge on components that control actin polymerization and organization.
整合素与肌动蛋白之间的联系正推动细胞迁移领域朝着新的方向发展。整合素与肌动蛋白通过一种物理连接耦合在一起，这种连接为迁移提供牵引力。最近的研究表明这种连接在调节黏附组织和发育中具有重要性。肌动蛋白聚合作用在迁移细胞前缘附近协调黏附组装，而肌动蛋白丝的动态交联促进黏附成熟。破坏肌动蛋白与整合素之间的连接会导致黏附解体。最近的定量研究揭示了肌动蛋白与整合素之间连接中的滑脱点，表明其并非总是高效的。黏附的组装、组织及其与肌动蛋白的连接的调节依赖于汇聚到控制肌动蛋白聚合和组织的成分上的信号通路。
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