Skyler Jay S
Diabetes Research Institute, Miami, Florida 33101-6960, USA.
Ann N Y Acad Sci. 2008 Dec;1150:190-6. doi: 10.1196/annals.1447.055.
This paper reviews worldwide efforts to interdict the type 1 diabetes (T1D) disease process, during the stage of evolution of the disease prior to the time of disease onset. The goal of intervention before disease onset is to arrest immune destruction and thus prevent or delay clinical disease. In this regard, there have been several large-scale multicenter randomized controlled clinical trials designed to prevent T1D. These have tested nicotinamide, parenteral insulin, oral insulin, nasal insulin, and the elimination of cow's milk from infant feeding.
本文回顾了在1型糖尿病（T1D）发病前疾病演变阶段，全球为阻断该疾病进程所做的努力。疾病发作前进行干预的目标是阻止免疫破坏，从而预防或延缓临床疾病的发生。在这方面，已经开展了几项旨在预防1型糖尿病的大规模多中心随机对照临床试验。这些试验对烟酰胺、胃肠外胰岛素、口服胰岛素、鼻用胰岛素以及婴儿喂养中去除牛奶进行了测试。
