McGilchrist C A, Aisbett C W
University of New South Wales, Kensington, Australia.
Biometrics. 1991 Jun;47(2):461-6.
In studies of survival, the hazard function for each individual may depend on observed risk variables but usually not all such variables are known or measurable. This unknown factor of the hazard function is usually termed the individual heterogeneity or frailty. When survival is time to the occurrence of a particular type of event and more than one such time may be obtained for each individual, frailty is a common factor among such recurrence times. A model including frailty is fitted to such repeated measures of recurrence times.
在生存研究中，每个个体的风险函数可能取决于观察到的风险变量，但通常并非所有此类变量都是已知的或可测量的。风险函数的这个未知因素通常被称为个体异质性或脆弱性。当生存时间是特定类型事件发生的时间，并且每个个体可能获得不止一个这样的时间时，脆弱性是这些复发时间之间的一个共同因素。一个包含脆弱性的模型被拟合到这种复发时间的重复测量中。
