Czeizel A E
Department of Human Genetics and Teratology, WHO Collaborating Centre for the Community Control of Hereditary Diseases, National Institute of Hygiene, Budapest, Hungary.
Biomed Pharmacother. 1991;45(6):249-54. doi: 10.1016/0753-3322(91)90025-o.
The annual and monthly distributions of congenital abnormalities and pregnancy outcomes as confounding factors were evaluated in Hungary in reflection of the accident at the Chernobyl reactor. The different congenital abnormality entities and the components of fetal radiation syndrome did not show a higher rate after the Chernobyl accident in the data-set of the Hungarian Congenital Abnormality Registry. Among confounding factors, the rate of induced abortions did not increase after the Chernobyl accident in Hungary. In the 9th month after the peak of public concern (May and June, 1986) the rate of livebirths decreased. Three indicator conditions: 15 sentinel anomalies as indicators of germinal dominant gene mutations, Down syndrome as an indicator of germinal numerical and structural chromosomal mutations, and unidentified multiple congenital abnormalities as indicators of germinal dominant gene and chromosomal mutations were selected from the material of the Hungarian Congenital Abnormality Registry. Diagnoses were checked, familial and sporadic cases were separated and only the sporadic cases were evaluated. The analysis of indicator conditions did not reveal any measurable germinal mutagenic effect of the Chernobyl accident in Hungary.
在匈牙利，结合切尔诺贝利反应堆事故，对作为混杂因素的先天性异常和妊娠结局的年度及月度分布情况进行了评估。在匈牙利先天性异常登记处的数据集中，切尔诺贝利事故后不同的先天性异常类型和胎儿辐射综合征的组成部分并未呈现出更高的发生率。在混杂因素中，匈牙利切尔诺贝利事故后人工流产率并未上升。在公众关注度达到峰值（1986年5月和6月）后的第9个月，活产率下降。从匈牙利先天性异常登记处的资料中选取了三种指标情况：15种作为生殖系显性基因突变指标的哨兵异常、作为生殖系染色体数目和结构突变指标的唐氏综合征，以及作为生殖系显性基因和染色体突变指标的不明原因多发先天性异常。对诊断结果进行了核查，区分了家族性和散发性病例，仅对散发性病例进行了评估。对指标情况的分析未发现切尔诺贝利事故在匈牙利对生殖系有任何可测量的诱变作用。
