基于全转录组分析对大肠杆菌生物膜形成及抑制的见解
Insights on Escherichia coli biofilm formation and inhibition from whole-transcriptome profiling.
作者信息
Wood Thomas K
机构信息
Artie McFerrin Department of Chemical Engineering, Texas A & M University, College Station, TX 77843-3122, USA.
出版信息
Environ Microbiol. 2009 Jan;11(1):1-15. doi: 10.1111/j.1462-2920.2008.01768.x.
Abstract
Biofilms transform independent cells into specialized cell communities. Here are presented some insights into biofilm formation ascertained with the best-characterized strain, Escherichia coli. Investigations of biofilm formation and inhibition with this strain using whole-transcriptome profiling coupled to phenotypic assays, in vivo DNA binding studies and isogenic mutants have led to discoveries related to the role of stress, to the role of intra- and interspecies cell signalling, to the impact of the environment on cell signalling, to biofilm inhibition by manipulating cell signalling, to the role of toxin/antitoxin genes in biofilm formation, and to the role of small RNAs on biofilm formation and dispersal. Hence, E. coli is an excellent resource for determining paradigms in biofilm formation and biofilm inhibition.
摘要
生物膜将独立的细胞转变为特殊的细胞群落。本文介绍了一些关于生物膜形成的见解，这些见解是通过特征最明确的菌株——大肠杆菌确定的。利用全转录组分析结合表型分析、体内DNA结合研究和同基因突变体对该菌株的生物膜形成及抑制进行的研究，已带来了一些发现，这些发现涉及应激的作用、种内和种间细胞信号传导的作用、环境对细胞信号传导的影响、通过操纵细胞信号传导抑制生物膜、毒素/抗毒素基因在生物膜形成中的作用以及小RNA在生物膜形成和分散中的作用。因此，大肠杆菌是确定生物膜形成和生物膜抑制范例的极佳资源。
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