差异刺激的CD4 + T细胞表现出改变的人类免疫缺陷病毒感染动力学：对抗病毒药物疗效的影响。
Differentially stimulated CD4+ T cells display altered human immunodeficiency virus infection kinetics: implications for the efficacy of antiviral agents.
作者信息
Vatakis Dimitrios N, Nixon Christopher C, Bristol Gregory, Zack Jerome A
机构信息
David Geffen School of Medicine at UCLA, Department of Medicine, Division of Hematology/Oncology, Los Angeles, California 90095, USA.
出版信息
J Virol. 2009 Apr;83(7):3374-8. doi: 10.1128/JVI.02161-08. Epub 2009 Jan 7.
Abstract
The activation state of CD4(+) T cells plays a crucial role in the establishment of a productive human immunodeficiency virus infection. Here, we show that T cells stimulated for 1 day demonstrated delayed kinetics of viral reverse transcription and integration compared to cells stimulated for 2 days prior to infection. As a result, the efficiency of reverse transcription and integration inhibitors differs in these differentially stimulated cells. These studies increase our understanding of how T cells support viral replication and provide insight regarding the efficiency of antiretroviral therapy in lymphoid compartments.
摘要
CD4(+) T细胞的激活状态在人类免疫缺陷病毒有效感染的建立过程中起着关键作用。在此，我们发现，与感染前刺激2天的细胞相比，刺激1天的T细胞表现出病毒逆转录和整合动力学延迟。因此，逆转录和整合抑制剂在这些不同刺激的细胞中的效率有所不同。这些研究增进了我们对T细胞如何支持病毒复制的理解，并为抗逆转录病毒疗法在淋巴组织中的效率提供了见解。
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