健康志愿者日常生活事件与5-羟色胺转运体和多巴胺转运体可用性之间的关系——一项双同位素单光子发射计算机断层扫描研究
The relationships between daily life events and the availabilities of serotonin transporters and dopamine transporters in healthy volunteers--a dual-isotope SPECT study.
作者信息
Yeh Tzung Lieh, Lee I Hui, Chen Kao Ching, Chen Po See, Yao Wei Jen, Yang Yeng Kuang, Chiu Nan Tsing, Lu Ru Band
机构信息
Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan.
出版信息
Neuroimage. 2009 Apr 1;45(2):275-9. doi: 10.1016/j.neuroimage.2008.12.004. Epub 2008 Dec 24.
The aim of this study was to examine the relationships between the daily life events and the availabilities of serotonin transporters (SERT) and dopamine transporters (DAT) in healthy volunteers. Thirty-seven volunteers, 19 males and 18 females, were recruited. The SERT availability was approximated using SPECT and [123I] ADAM while the DAT availability was approximated using SPECT and [99mTc] TRODAT-1. All participants completed the Recent Life Change Questionnaire. The results showed that SERT and DAT may be sensitive to the presence of stressful events.
本研究的目的是探讨健康志愿者的日常生活事件与血清素转运体（SERT）和多巴胺转运体（DAT）可用性之间的关系。招募了37名志愿者，其中19名男性和18名女性。使用单光子发射计算机断层扫描（SPECT）和[123I] ADAM来估算SERT的可用性，而使用SPECT和[99mTc] TRODAT-1来估算DAT的可用性。所有参与者都完成了近期生活变化问卷。结果表明，SERT和DAT可能对应激事件的存在敏感。
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