Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan.
Psychiatry Res. 2010 Dec 30;184(3):157-61. doi: 10.1016/j.pscychresns.2010.09.004. Epub 2010 Oct 27.
Serotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depression who are in a depressed state in comparison with healthy controls. The aim of this study was to examine the distribution volume ratios (DVRs) of SERT and DAT in drug-free and euthymic patients with a history of major depression. Subjects comprised 13 patients with a history of major depression and 26 sex- and age-matched healthy controls. The euthymic state of depression was defined as a score of 7 or less on the Hamilton Depression Rating Scale. The DVRs of SERT and DAT were approximated using SPECT, with [(123)I] 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM) and [(99m)Tc] TRODAT-1 as the ligands, respectively. There were no significant differences in the DVRs of SERT or DAT between healthy subjects and euthymic patients with a history of major depression; hence, the SERT and DAT DVRs may not therefore be trait markers for patients with major depression, which helps us to understand more about the pathophysiology of depression.
与健康对照组相比，处于抑郁状态的重度抑郁症患者的 5-羟色胺转运体（SERT）和多巴胺转运体（DAT）水平存在差异。本研究旨在探讨无药物治疗且既往有重度抑郁症病史的患者中 SERT 和 DAT 的分布容积比值（DVR）。研究对象包括 13 名有重度抑郁症病史的患者和 26 名性别和年龄匹配的健康对照者。抑郁的缓解状态定义为汉密尔顿抑郁量表评分为 7 或更低。使用 SPECT 来近似 SERT 和 DAT 的 DVR，分别使用 [(123)I] 2-((2-((二甲氨基)甲基)苯基)硫)-5-碘代苯乙胺（ADAM）和 [(99m)Tc] TRODAT-1 作为配体。健康受试者与既往有重度抑郁症病史且处于缓解状态的患者之间的 SERT 或 DAT 的 DVR 无显著差异；因此，SERT 和 DAT 的 DVR 可能不是重度抑郁症患者的特征性标志物，这有助于我们更深入地了解抑郁症的病理生理学。
